BIOL2254 Tutorial 3 Assessment Ruic Semester 2, 2021 Page 1 of 4 RMIT Classification: Trusted Part...

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BIOL2254 Tutorial 3 Assessment Ruic Semester 2, 2021 Page 1 of 4   RMIT Classification: Trusted Part 1 Ruic:  High Distinction Distinction Credit Pass Not satisfactory Total Marks All questions There is an advanced and thorough understanding of the bioinformatics approaches used in the chosen research article, including an understanding of data sources/controls/similar techniques. There is a strong understanding of the ioinformatics approaches used in the chosen esearch article, including an understanding of data sources/controls/similar techniques. There may be minor omissions or eors.There is a reasonable understanding of the ioinformatics approaches used in the chosen research article. There may be omissions or eors.There is limited understanding of the ioinformatics approaches used in the chosen research article. There are major omissions or eors.There is an inadequate understanding of the bioinformatics approaches used in the chosen research article. 50 points       Total:      /50 BIOL2254 Tutorial 3 Assessment Ruic Semester 2, 2021 Page 2 of 4   RMIT Classification: Trusted Part 2 Ruic:  High Distinction Distinction Credit Pass Not satisfactory Total Marks Introduction Introduction clearly introduces the topic and oader context, demonstrating an advanced understanding of the oader research field. Key bioinformatics terms are defined clearly and simply. Introduction includes an appropriate level of detail to enable a general scientific audience to understand the research eing discussed. Introduction clearly introduces the topic and oader context, demonstrating a good understanding of the oader research field. Key bioinformatics terms are defined.  Introduction includes an appropriate level of detail to enable a general scientific audience to understand the esearch being discussed. There may e minor eors in understanding.  Introduction introduces the topic and oader context, demonstrating a easonable understanding of the oader research field. Key bioinformatics terms may be defined but are difficult to understand from the description.  There may be eors in understanding.  Introduction adequately describes the topic, demonstrating an acceptable understanding of the oader research field. Key bioinformatics terms are either defined poorly or otherwise missing.  There are major eors in understanding.  Introduction does not adequately describe the topic. Key bioinformatics terms are not defined. There are major eors in understanding.  10 points Body Discussion of chosen esearch article is clear and articulate, demonstrating an advanced understanding of the chosen research article and suounding work. Scientific language used is appropriate for a general scientific audience, with key ioinformatics concepts clearly explained.  Discussion of chosen esearch article is generally clear and articulate, demonstrating a good understanding of the chosen research article. Scientific language used is generally appropriate for a general scientific audience, with key ioinformatics Discussion of chosen esearch article demonstrates a easonable understanding of the chosen research article. Scientific language used is generally appropriate for a general scientific audience, although there may be unnecessary use of overly technical language. Key ioinformatics concepts Discussion of chosen esearch article demonstrates an acceptable understanding of the chosen research article. Scientific language used may be inappropriate for a general scientific audience, with unnecessary use of overly technical language. There is an Discussion of chosen esearch article demonstrates an inadequate understanding of the chosen research article. Scientific language used is inappropriate for a general scientific audience. Key ioinformatics concepts are not explained.  20 points  BIOL2254 Tutorial 3 Assessment Ruic Semester 2, 2021 Page 3 of 4   RMIT Classification: Trusted concepts clearly explained. There may e minor eors in understanding.are explained, although these explanations may e overly convoluted or otherwise inadequate. There may be eors in understanding.attempt to explain key ioinformatics concepts, although these explanations are overly technical or otherwise flawed. There may be major eors in understanding.Conclusion and future directions Response contains a clear conclusion that accurately summarizes the major advances made in the chosen esearch article, as well as providing well-esearched and insightful suggestions for future esearch.  Response contains a clear conclusion that summarizes the major advances made in the chosen research article, as well as providing suggestions for future research. There may be minor eors in understanding.Response contains a conclusion that summarizes some of the advances made in the chosen research article. Suggestions for future esearch are present but may be poorly esearched. There may be eors in understanding.Response contains a conclusion that adequately summarizes the chosen research article. Suggestions for future research are absent. There are significant eors in understanding.Response does not contain a conclusion or contains a conclusion that does not adequately summarize the chosen esearch article.10 points Presentation (grammar, sentence structure, spelling, formatting) Minimal spelling & grammatical eors. Writing style is appropriate to the task. Document is formatted appropriately (including headefootepage numbers). Some spelling & grammatical eors. Writing style is mostly appropriate to the task. Document is generally formatted appropriately.A reasonable number of spelling & grammatical eors. Writing style is mostly appropriate to the task at times, but with lapses throughout. Document formatting may need improvement.Spelling & grammatical eors throughout but do not interfere with meaning. Writing style may be overly informal or not appropriately suited to the task. Document formatting needs considerable improvement.Consistent spelling & grammatical eors throughout that make understanding difficult. Writing style is not appropriate for to the task. Document formatting is unsatisfactory.5 points  BIOL2254 Tutorial 3 Assessment Ruic Semester 2, 2021 Page 4 of 4   RMIT Classification: Trusted Referencing References consistently conform to the appropriate referencing conventions, both in-text and in the reference listReferences mostly conform to the appropriate eferencing conventions, both in-text and in the eference listReferences generally conform to the appropriate referencing conventions, both in-text and in the reference listReferences generally conform to the appropriate referencing conventions, both in-text and in the eference list, with some lapsesReferences do not conform to the appropriate referencing conventions, in text and/or in the reference list5 points       Total:     /50

Preeti · Accepted Answer

Myc
Myc (avian myelocytomatosis viral oncogene homolog), a family of regulator genes and protooncogenes, encodes for the transcription factor. The studies says that Myc is involved in trigger of selective gene expression amplification that leads to cell growth and proliferation (Stine et al., 2015). The Myc family includes three genes related to humans: c-myc, l-myc, and n-myc. The c-myc or v-myc, was the first myc protein that was discovered in 1970s. In an avian acute leukaemia virus (MC29), which is involved in promotion of malignancies and the transforming sequence of MC29 was identified as v-myc. The discovery of Myc leads to the realization that transformation of an oncogene could be caused by the cellular gene activation (Wasylishen & Penn, 2010). Thus, Myc leads to the understanding of how the cellular genes are involved in the tumorigenesis. Myc are involved in several biological functions. These include: Myc is involved in the cell growth and its proliferation both in vitro and in vivo. The increase in cell growth was due to increase in protein synthesis and cellular metabolism (Iritani & Eisenman, 1999; Schuhmacher et al., 1999). This activity is being supported by many of the universally regulated Myc target genes, even those which are included in mitochondrial and ribosomal biogenesis, cell metabolism, protein synthesis and nucleic acid synthesis (Wasylishen & Penn, 2010). It has also been studied that deregulated Myc have high rate for specific gene amplifications and involved in instability of the chromosomes. The Myc are also being studied in their involvement in the stimulation of neovascularization, which has also been validated in several in vivo models. This is mainly because of angiogenesis suppresser thrombospondin downregulation and also because of the release of interleukin 1β. In recent studies, the Warburg effect and tumour cell metabolism has been associated with Myc biological activity. It has also been studied that Myc is involved in the promotion of glutaminolysis (Dang et al., 2009). This increase in glutamine production has been associated with increase in cell proliferation and growth, which are important for the survival of tumour cells. It has been recently studied that overexpression of Myc gene could be involved in reprogram of terminally differentiated fibroblasts and its induction to pluripotent stem cells (Wernig et al., 2007). 
Figure 1: Myc protein and its involvement in various biological activities  (Wang et al., 2021)
The transcription factor c-Myc plays an essential role in the maintenance of homeostasis of cell, and its deregulation has been associated with several cancer and hence, Myc protein can be considered as a good target for the development of cancer therapeutics. There have been many studies that involves the generation of cancer therapeutics against the Myc protein. Some of them are discussed below:
In a recent study by Singh et al., an in-silico alanine scanning mutagenesis has been used for the identification of hot spot residues at the X interface of c-Myc associated factor. This is highly disordered and has not been analysed for the binding sites for potential small molecules. In this study, they screened some potential inhibitor molecules by following conformation ensemble approach.  They also used biophysical approach and has identified that the putative molecules with these hot spot residues displayed the non-covalent interactions. They also performed the in vitro studied and validated the potency of these molecules by deregulating the Myc activity against the c-Myc expressing cancer or stem cells. The computational as well as the biophysical studies confirmed the binding of these potent molecules with the disordered c-Myc protein (Singh et al., 2022).
In a recent study the researchers discovered MYCi975 using bioinformatic approach,

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