What are immunoglobulis and types of immunoglobulins?

Question

David · Accepted Answer

TYPES OF IMMUNOGLOBULINS 
An Antibody (Ab), also known as an immunoglobulin (Ig), is a large, 
Y-shaped protein produced mainly plasma cells that is used by the 
immune system to neutralize  pathogens such as bacteria and viruses. 
The antibody recognizes a unique molecule of the harmful agent called 
antigen via the Fab’s variable region.
IgM Antibody 
IgM is a polymer, where multiple immunoglobulins are linked together 
by strong  covalent bonds known as  disulfide bonds. This occurs mostly 
to produce pentamers (5 linked immunoglobulins) but also as a hexamer 
(six linked immunoglobulins). 
 IgM has a  molecular mass of approximately 970 kDa(in its pentamer 
form). Because each immunoglobulin  monomer  has two antigen 
binding sites, a pentameric IgM has 10 binding sites.  
Typically, however, IgM cannot bind 10 antigens at the same time 
because the large size of most antigens hinders binding to nearby sites. 
https://en.wikipedia.org/wiki/Monomer
https://en.wikipedia.org/wiki/File:Antibody.svg
The j chain is found in pentameric IgM but not in the hexameric form, 
perhaps due to space constraints in the hexameric complex. 
 Pentameric IgM can also be made in the absence of J chain. At present, 
it is still uncertain what fraction of normal pentamer contains J chain, 
and to this extent it is also uncertain whether a J chain-containing 
pentamer contains one or more than one J chain. 
 Although hexameric IgM without J chain has higher efficiency of  
complement fixation than pentameric IgM with J chain.  
Because IgM is a large molecule, it cannot diffusewell, and is found in 
the interstitiumonly in very low quantities. IgM is primarily found in 
serum however, because of the J chain, it is also important as a secretory 
immunoglobulin. Due to its polymeric nature, IgM possesses high 
avidity  and is particularly effective at complement activation.
The structure of the IgE antibody
The role of mast cells in the development of allergy.
Degranulation processes 1 - antigen; 2 - IgE antibody; 3 - FcεRI 
receptor; 4 - preformed mediators (histamine, proteases, chemokines, 
heparin); 5 - granules; 6 - mast cell; 7 - newly formed mediators 
(prostaglandins, leukotrienes, thromboxanes,

What are immunoglobulis and types of immunoglobulins?

Solution

Answer To This Question Is Available To Download

Related Questions & Answers

Submit New Assignment