TOPICthe use of functional genomics in cancer research.The literature review should consists of an...

Question

TOPICthe use of functional genomics in cancer research.

The literature review should consists of an Introduction, a main body and a conclusion
Total marks available are 30
Please submit your literature review onto CANVAS by the due date. You can submit a single Word Document/PDF file.

Guide

A literature review is an exploration of the published literature on a particular topic. Sources of the published literaturemay include scholarly journal articles, books, government reports, and other sources. It has an introduction, a body and a conclusion.

Title (1 mark): A concise title of no more than 15 words
Introduction (5 marks)

Provide background on the topic and its importance, and state your objective.

Body (15 marks)

- Provide a description, summary and evaluation of each source and combine them into a logical whole.

- Analyse and interpret the literature, do not just paraphrase them

- Use subheadings, create a logical structure of the review

Conclusion (5 marks)

Summarise the key findings, emphasise their significance and suggestions forfuture research.

References and language (4 mark)

- References cited in text must appear in the reference list and vice versa (except for the sources whenno author can be identified - theseare cited in text and are not included in the reference list).

- Be consistent with the formatting style

-Clear and concise writing style.

-Appropriate use of scientific language.

Learning Objectives Assessed:

This assessment supports CLOs 1, 4, 5, 6 & 7

Rubric

Literature review rubric

Criteria

Ratings

Pts

This criterion is linked to a learning outcomeTitle

A concise title of no more than 15 words

1Pts

Very Good

The title is concise and not more than 15 words

0.63Pts

Good

It is understandable but not very concise

0.25Pts

Poor

It's too hard to understand, and too long

0Pts

Fail

The title is totally irrelevant to the body of the literature

1pts

This criterion is linked to a learning outcomeIntroduction

Provide background on the topic and its important, and state your objective

5Pts

Very good

Excellent topic background and its important and the objective of the review is clearly stated

3Pts

Good

Good background of the topic and the objective is clear. There may be some minor inaccuracies in the information.

2Pts

Poor

The background and objective are poorly written and not very relevant to the topic

0Pts

Fail

No relevant information

5pts

This criterion is linked to a learning outcomeBody

- Provide a description, summary and evaluation of each source and combine them into a logical whole.
- Analyse and interpret the literature, do not just paraphrase them
- The articles reviewed are clearly inter-related
- Use subheadings, create a logical structure of the review

15Pts

Very Good

Information obtained from each source are exceptionally communicated, combined and analysed. The structure is logical organised and clear.

11.25Pts

Good

Information are organised, interpreted and communicated well. Some statements may contain minor error.

5Pts

Poor

The literature isn't analysed and most are wrongly interpreted.

0Pts

Fail

No relevant information

15pts

This criterion is linked to a learning outcomeConclusion

Summarise the key findings, emphasise their significance and suggestions for future research.

5Pts

Very Good

Clear and logical conclusions are drawn from the scientific literature and limitations are identified.

3.75Pts

Good

Conclusions are clear but may contain some gaps in logic.

1.25Pts

Poor

Conclusions contain large gaps in logic

0Pts

Fail

No conclusion or it's irrelevant

5pts

This criterion is linked to a learning outcomeReferences

- References cited in text must appear in the reference list and vice versa (except for the sources when no author can be identified - these are cited in text and are not included in the reference list).
- Be consistent with the formatting style
- Write in a clear and concise way
-Appropriate use of scientific language

4Pts

Very Good

Information is correctly referenced –in-text and in reference list. The formatting style is used consistently through the review. The review is well written and concise and scientific language is used well.

3Pts

Good

Missing one or two references or the formatting style is not consistently used. Writing style is reasonable, although some grammatical or scientific errors.

1Pts

Poor

Many references cited in text but not appear in the reference list and different formatting styles were used. The writing is very unclear and the use of scientific terms is not appropriate.

0Pts

Fail

No reference list. Writing is poor or only partially completed. Poorly used scientific terms.

4pts

Total points:30

Dr Raghunandan G · Accepted Answer

· A Review on Importance of Functional Genomics in Study of Cancer
1.Introduction 
The functional genomics approach to the study of cancer biology has a great deal of promise. Understanding the interplay between genes, proteins, and other cellular components to generate an observed phenotype is central to the field of functional genomics. The field of functional genomics investigates the context-dependent changes in the expression of gene products. It is possible to elucidate the malignant growth, metastases, and treatment approaches are governed by genetic collaboration and cellular specifics as a result of rigorous methods for altering specific genes in conjunction with statistical tests of carcinoma genetic traits caused by genetic as well as epigenetic changes. These technologies have made it possible to study cancer in greater detail. Because of this, it is now feasible to understand the variables that drive oncogenesis, the spread of cancer, and how well patients respond to treatment. Multiplexed genetic perturbations make it possible to analyze cooperative genetic lesions and to locate gene pairs that are synthetically lethal. This is possible because of the versatility of multiplexed genetic perturbations. These gene pairs offer special promise for the construction of new cancer therapeutics. In this analysis, we focus on the impact of both traditional and modern gene function techniques on the landscape of cancer research. Research in functional genomics investigates the role that the genome plays in the development of cancer. Systems biology analysis found trends in the genetics of disease that, in certain cases, can be added directly to the provision of precise cancer therapy. This is done by confirming theories developed via functional gene sequencing or by developing fresh ideas through work with cancerous cells.
2.Importance of Functional Genomics: Background work
A set of genes that are commonly modified, amplified, or deleted are shared by a number of distinct forms of cancer. In many cases, our understanding of the ways in which the stimulation or silencing of these chromosomes coordinate the growth of tumors is limited, despite the availability of data pertaining to genomics. (Bailey et al. 2018). In addition, mutations, amplifications, and deletions of multiple genes that are essential for the biology of tumors and the process of oncogenesis are rare (Luo et al. 2009). In many cases, it is unknown which gene products drive tumor spread, affect the tumor micro environment, either prevent cancerous cells from being recognized by the inflammatory response or increase treatment sensitivity. This can be a significant obstacle in the treatment of cancer. In reality, it is highly likely that the synchronized activity of a significant number of genes determines tissue specific morphologies for all of these aggressive disease.

TOPICthe use of functional genomics in cancer research.The literature review should consists of an Introduction, a main body and a conclusionTotal marks available are 30Please submit your literature...

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