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1 Assessment Brief Assessment Brief_L5_SDB_2022/23 Read this assessment brief carefully, it tells you how you are going to be assessed, how to submit your assessment on-time...

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Assessment Brief

Assessment Brief_L5_SDB_2022/23


Read this assessment
ief carefully, it tells you how you are going to be assessed, how to
submit your assessment on-time and how (and when) you’ll receive your marks and
feedback.

Module Code ASC_5_SDB_2023
Module Title Stem Cell and Developmental Biology
Lecturer Alison Alvarez and Valentina Caputo
% of Module Mark 50%
Distributed [26/09/2022]
Submission Method Submit online via this Module’s Moodle site
Submission Deadline
CW1 (25% XXXXXXXXXX:59pm
CW2 (25% XXXXXXXXXXam-17 pm
Release of Feedback Feedback will be available online from [18/01/23]
Release of Marks
Provisional marks will be available in Moodle from
XXXXXXXXXX
Assessment:
Part A: Group Research Review. Topic to be chosen by the group (Self-elected 4
students). The mark will be for the whole group
Part B: Presentation of the research work by Poster and an oral presentation.
Students will be marked individually.
The final mark of assessment will be the average between 2 marks.
2
Assessment Details:
Assessment of your work will consider

A. content and the quality of your scientific writing.

You have an opportunity to apply the subject knowledge that you have acquired and
einforced during this semester.
This will be assessed according to the following strands:

1. Research
Systematic identification and use of academic and relevant resources

2. Subject Knowledge
Understanding and application of subject knowledge. Contribution to subject
debate by updated research


B. the quality of your scientific writing

Structure, quality and clarity of argument, coherence, use of evidential support and
eferencing, spelling, grammar and punctuation.
This will be assessed according to the following strands:

7. Communication and Presentation
Clear intention in communication. Audience needs are predicted
and met. Presentation format is used skillfully. Work is well
structured.

8. Academic Integrity
Acknowledges and gives credit to the work of others follows the
conventions and practices of the discipline including appropriate use
of referencing standards for discipline.
















3
Type: Group Research Review, poster and oral presentation
Resources: Suggested core textbooks detailed on the course guide.

Coursework Part A resources page, scientific literature
(PUBMED)

Coursework Part B resources page, scientific drawing
(BioRender)
Word Count: Part A: Research Review- As a guide, aim for 3000
words. The maximum word limit is 3300 words,
minimum 2700 words
References, tables and appendixes will not count
towards word count totals
If the total word limit is exceeded, a 5% penalty for every
100 words over will be applied to the overall mark.
Part B- Poster- A1 or A0. All the group members should
e able to present/explain the poster to public and peers.
The group should
ing the printed poster to the oral
presentation session.
Oral presentation: each team member will present part
of the work for 5 min. All the team members should
answer questions.
Presentation: Part A
ï‚· The research review must contain:
Short abstract (summary of the review)
Introduction (definition of the main subject). Set
the scene.
Brief story of the topic. What was discover and
when
Main advances/milestones.
Controversies or public perception
Future directions.
Personal perspectives
ï‚· Work must have figures, graphs and tables to help
explain concepts and summarize information
ï‚· Work must be referenced
ï‚· Work must be submitted as a Word document
(.doc/docx)
ï‚· Course work must be submitted using Arial font size
11 (or larger if you need to), with a minimum of 1.5
line spacing
4
 Your student’s numbers must appear at the front of
the coursework. Your name must not be on your
coursework.

Part B
ï‚· Poster and presentation slides must be referenced
ï‚· Poster and presentation slides must be submitted
as a PowerPoint document (.ppt)
Referencing: Harvard Referencing should be used, see your Li
ary
Subject Guide for guides and tips on referencing.
Regulations: Make sure you understand the University Regulations on
expected academic practice and academic misconduct.
Note in particular:
â–ª Your work must be your own. Markers will be
attentive to both the plausibility of the sources
provided as well as the consistency and approach to
writing of the work. Simply, if you do the research
and reading, and then write it up on your own, giving
the reference to sources, you will approach the work
in the appropriate way and will cause not give
markers reason to question the authenticity of the
work.
â–ª All quotations must be credited and properly
eferenced. Paraphrasing is still regarded as plagiarism
if you fail to acknowledge the source for the ideas
eing expressed.

TURNITIN: When you upload your work to the Moodle
site it will be checked by anti-plagiarism software. 15%
Turnitin score is the maximum allowed.


Learning Outcomes
This assessment will fully or partially assess the following learning outcomes for this
module.

Knowledge and Understanding
Develop understanding of advanced concepts in cellular and developmental
iology.
Cu
ent and potential uses of stem cells in therapy
Intellectual Skills
https:
libguides.lsbu.ac.uk/subjects/home
https:
libguides.lsbu.ac.uk/subjects/home
http:
www.lsbu.ac.uk/__data/assets/pdf_file/0008/84347/academic-regulations.pdf

5
Explain the fundamental principles, techniques and applications of stem cell
esearch
Transferable Skills
• Develop skills in research and critical scientific writing and oral communication
Assessment Criteria and Weighting
LSBU marking criteria have been developed to help tutors give you clear and helpful
feedback on your work. They will be applied to your work to help you understand
what you have accomplished, how any mark given was a
ived at, and how you can
improve your work in future.

PART A: Research Review
Criteria
Feedforward
comments
100-80% 79-70% 69-60% 59-50% 49-40% 39-30% 29-0%
7
0
%
2. Subject
Knowledge
Understanding
and application
of subject
knowledge.
Contribution to
subject debate.
Shows sustained
eadth, accuracy and
detail in understanding
key aspects of subject.
Contributes to subject
debate. Awareness of
ambiguities and
limitations of
knowledge.
Shows
eadth,
accuracy and detail in
understanding key
aspects of subject.
Contributes to subject
debate. Some
awareness of
ambiguities and
limitations of
knowledge.
Accurate and
extensive
understanding of key
aspects of subject.
Evidence of
coherent knowledge.
Accurate
understandin
g of key
aspects of
subject.
Evidence of
coherent
knowledge.
Understanding
of key aspects
of subject.
Some
evidence of
coherent
knowledge.
Some
evidence of
superficial
understanding
of subject.
Inaccuracies.
Little or no
evidence of
understandin
g of subject.
Inaccuracies.
3
0
%
7.
Communicatio
n and
Presentation
Clear intention
in
communication.
Audience
needs are
predicted and
met.
Presentation
format is used
skilfully. Work
is well
structured.
Communication is
entirely clear,
persuasive and
compelling with very
skilful use of the
presentation format.
Presentation addresses
fully the needs of the
audience.
Communication is
clear, persuasive and
compelling with very
skilful use of the
presentation format.
Presentation
addresses fully the
needs of the
audience.
Communication is
clear, mostly
persuasive and
compelling with
skilful use of the
presentation format.
Presentation
addresses the needs
of the audience.
Communicati
on is clear,
with skilful
use of the
presentation
format.
Presentation
takes into
account the
needs of the
audience.
Communicatio
n is mostly
clear and
presentation
format is
adequate.
Presentation
may
sometimes not
take into
account the
needs of the
audience.
Communicatio
n is unclear
ecause
presentation
format is not
used
adequately
and/or the
needs of the
audience are
not taken into
account.
Communicati
on is very
unclear
ecause
presentation
format is not
used
adequately,
and the
needs of the
audience are
not taken
into account.

6
Breakdown of criteria:
Quality Exceeds Expectations (4) Meets Expectations (3) Acceptable (2) Unacceptable (1)
Content (70%)
Explanation of
significance (15%)
Present, co
ect, complete. Writing is
dynamic, and engages ready attention
Present, adequately complete, co
ect.
Explanation is well written, contains
asic info.
Present, somewhat incomplete, some
e
ors. Contains necessary info, but
awkward.
Not present or very limited, or major
e
ors. Significance of research is lost.
Summary of
esearch findings
(30%)
Main conclusions, supporting and
evidence are fully explained and are
co
ect interpretations of the paper
Main conclusions, supporting evidence
are adequately explained, and mostly
co
ect with no or minor technical e
ors
in interpretation.
Main conclusions and supporting
evidence are partially explained, or have
some inco
ect interpretations.
Main conclusions and supportive
evidence are minimally explained, or
there are some major e
ors in
interpretation.
Inclusion of
ackground
information (10%)
Relevant background is fully included
and is co
ect
Relevant background information is
present at adequate levels, and is
co
ect
Relevant background information is
insufficient, or moderately inco
ect.
Relevant background information is
missing or highly inco
ect
Explanation of
figure/graph/ table
(15%)
Strong choice of figure, is fully
explained, and is a co
ect interpretation
Reasonable choice of figure, is
adequately explained, and is a co
ect
interpretation with no or minor technical
e
ors
Reasonable choice of figure, is partially
explained, and has some inco
ect
interpretations
No figure given, or minimal/no
explanation. May have major e
ors in
interpretation.
Format and style (30%)
References and
use of direct
quotations (10%)
In-text Harvard style citations are used
co
ectly where required. No more than
two quotations are used.
In-text Harvard style citations are used
co
ectly where required, with no more
than two minor formatting e
ors. No
more than two quotations are used.
In-text citations are used where
equired, in an inco
ect style; and/or,
three quotations are used.
Outside material/information is not cited;
and/or more than four quotations are
used.
Structure (5%) Between 725 and 775 words, with
co
ect margins and font. Written in
clear paragraphs, structured in inverted
pyramid format.
Between 725 and 775 words, with minor
e
ors in margins or font. Written in
clear paragraphs, structured in inverted
pyramid format.
More than 775 words or less than 725
words. E
ors in margins, font, and/or
paragraph structure. Inverted pyramid
elements are present, but not in co
ect
order.
More than 825 or less than 675 words.
E
ors in margins, font, /or and
paragraph structure. Lacks any
organizational structure. Essential
information is lost.
Language level
and clarity (10%)
Always comprehensible without having
to refer to original paper or other
sources; any specialized vocabulary is
defined and necessary; language is
neither too technical nor too simple.
Almost always comprehensible without
having to refer to original paper or other
sources; any specialized vocabulary is
defined and necessary; language is
occasionally too technical or too simple.
Sometimes comprehensible without
having to refer to original paper or other
sources; unnecessary specialized
vocabulary is used; language is
somewhat too technical or too simple.
Largely incomprehensible; cannot be
understood without having to refer to
original paper or other sources;
vocabulary is either highly technical or
highly simplified.
Spelling/ Grammar
(5%)
No e
ors in spelling or grammar; all
acronyms are defined.
Two or fewer
Answered 1 days After Dec 12, 2022

Solution

Dr Insiyah R. answered on Dec 13 2022
31 Votes
Introduction    1
Conclusion    8
Reference    8
Introduction
A stem cell is a developmental biology term for an unspecialised cell that may divide indefinitely and differentiate into the specialised cells that make up the body's organs and tissues by activating or inactivating a number of genes. Many scientists believed literature on human stem cells had extraordinary promise for advancing biological understanding and treating a wide range of diseases at the start of the twenty-first century (Ang et al,2018). Research involving stem cells is helping us understand how animals grow from a single cell, including how healthy cells repair damaged ones in adult creatures. One of the most exciting areas of modern biology is stem cell research, but like many
anches of science still developing, it raises more questions than answers.
Main advances/milestones.
What distinguishing characteristics do all stem cells share? Unlike other types of cells in the body, stem cells are unique. Regardless of their origin, all stem cells share three characteristics: they can divide and regenerate themselves for extended periods; they are unspecialised, and they can develop into different specialised cell types. Stem cells may reproduce several times, unlike muscle, blood, or nerve cells, which do not often do so (Ang et al,2018). Millions of cells may be produced from a beginning community of stem cells that grow over several months in the lab. The cells are thought to be capable of long-term self-renewal if they continue to be unspecialised such as the parent stem cells. Stem cells come in various forms, including adult, em
yonic, and induced undifferentiated. I'll go through each one's advantages and disadvantages in
ief. Adult stem cells are now thought to be less likely to cause transplant-related rejection. This is due to the possibility of growing a patient's cells in culture, encouraging them to take on certain types of cells, and then reintroducing them into the patient (Jiang and Xu,2020).
Pluripotent stem cells (PSCs) hold promise in various scientific fields, particularly in diagnosing diseases. A potentially infinite supply of induced pluripotent stem cells (iPSCs) allows for the expansion, differentiation, and analysis of afflicted human cells without using an additional animal model (Shahbazi et al,2019). This is accomplished by converting donated somatic cells with disease morphology. The identification of disease pathways can be accelerated by using physiologically appropriate cellular models. It has been established that genome editing in induced pluripotent stem cells (iPSCs) is a highly efficient method for creating disease models for both monogenic and complicated genetic illnesses. Researchers may explore how diseases impact certain cell types using iPSCs as disease models. The high level of patient-to-patient heterogeneity introduced by isogenic illness models that contrast healthy donor cells with sick donor cells might skew the outcomes of experiments. Modern genome editing techniques like CRISPR, Cas9, and TALEN systems now make it possible to create human isogenic controls with lower variability, which can assist in reducing these issues. By removing the genetic heterogeneity from patient to patient, the capacity to design cells produces clear advantages that result in more consistent phenotypes with each trial (Liu et al,2020).
Although it is unknown whether the cells can colonise every tissue in a human em
yo, it is assumed, based on the other characteristics, that they are pluripotent cells. As a result, they are viewed as a potential source of specialised cells for cell therapy, which involves replacing a patient's malfunctioning cell type with healthy cells. It is possible to create large numbers of cells from em
yonic stem cells for cell transplantation, including dopamine-secreting neurones for the treatment of Parkinson's disease and insulin-secreting pancreatic beta lymphocytes for the treatment of diabetes (Berg et al,2019).
Within two weeks of the damage, patients' bone ma
ow liquid was collected, and mesenchymal stem cells were isolated and multiplied in great quantities. Within 54 days following the injury, the patient received the preparation injection intravenously. The study showed that given stem cells collected in the spinal cord's damaged regions and stimulated tissue regeneration.
Keratinocytes are a kind of cell found in layers of the skin's epidermis. Only the cells in the basal layer, which is located near the dermis, may divide. Though the bulk of these cells is transit amplifying cells, some are stem cells (Gowen et al,2020). As they mature, the keratinocytes slowly protrude through the epidermis before dying and being shed off at the skin's surface. Small pits called crypts and projections called villi are formed by the small intestine's epithelium. The stem cells are found close to the base of each crypt, whereas the dividing cells are found inside the crypts. Continuous cell production occurs in the crypts, where they go to the villi and are finally shed into the gut lumen.
Hematopoietic stem cells are found in the bone ma
ow, which gives rise to all blood and immune system cell types. In smaller amounts in peripheral blood and higher concentrations in umbilical cord blood, hematopoietic stem cells can also be identified. Hematopoietic stem cells are attached to blood arteries and osteoblasts of trabecular in the bone ma
ow (Chaicharoenaudomrung, Kunhorm and Noise,2019). They produce offspring that, depending on the ratio of growth factors in their immediate su
oundings, can develop into lymphocytes, red blood cells, granulocytes and a few other types of cells.
Animal experiments have demonstrated that hematopoietic stem cell transplants can occasionally colonise other organs, resulting in the transplanted cells developing into neurones, muscle cells, or endothelium (McQuade et al,2018). It is scarce for engraftment hematopoietic stem cells to colonise other organs successfully. Despite this, hematopoietic stem cell transplantation is being investigated as a treatment for ailments such as autoimmune diseases and heart disease. It is a particularly alluring alternative for people who are against the usage of stem cells.
The immune system would be less likely to reject the adult stem cells if they were used, as would tissues made from the patient's adult stem cells. Advantages: Success has already been shown in several clinical applications, and it is anticipated to be less susceptible to...
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