24/05/2021 Peptide mediators poster https://rmit.instructure.com/courses/79108/assignments/ XXXXXXXXXX/3 Peptide mediators poster Due Monday by 9:00 Points 100 Submitting a file upload File types pdf...

24/05/2021 Peptide mediators poste
https:
mit.instructure.com/courses/79108/assignments/ XXXXXXXXXX/3
Peptide mediators poster
Due Monday by 9:00 Points 100 Submitting a file upload File types pdf Available after 1 Mar at 9:00
Start Assignment
COURSE NAME:  Principles of Pharmacology
COURSE CODE: ONPS2032
ASSIGNMENT TITLE: Peptide mediators poster
WEIGHTING:   20%
DUE DATE: Monday May 31st, 9am
This assessment task supports CLOs 1, 2, and 5.
Peptide Mediators assignment - Drugs to affect appetite
Introduction
Peptide mediators are important physiological regulators. This activity investigates the physiology and pharmacology of peptide mediators in appetite, feeding, and satiety
(feeling full). These are complex processes that are regulated by many different neuropeptide mediators.
In this exercise, you will investigate the physiology and pharmacology of a peptide mediator that is involved in feeding and satiety. Using this research, you will design a
theoretical drug that targets a part of this peptide pathway in order to reduce food intake. You will then prepare a poster that presents the pharmacology of your peptide
mediator pathway, and explains how the drug you have designed will interfere with this pathway to reduce food intake. The video below contains a summary of this task. 
 
Task
Your task is to design a  theoretical drug that will act on the physiological pathway (e.g. production, action, termination) of your peptide and reduce food intake (i.e. a new
‘diet pill’). The video lectures on Peptide Mediators by A/Prof Trisha Jenkins (available by week 9) will help you to understand and complete this task.
We have selected a short-list of endogenous neuropeptides that can regulate some aspect(s) of feeding and satiety. You will select one of these neuropeptides as the topic
for their poster. Peptide selections will open on Canvas in week 8, when you will be able to select a peptide by joining a 'Group' on Canvas.  Once you open the 'Groups'
section you will see a number of groups, one for each peptide. To select a peptide, simple assign yourself to that group. Please note that there are a limited number of
students who can select each peptide – once a 'Group' is full, no other students can select that peptide. Any students who have not selected a peptide on Canvas by
Monday May 3rd (week 9) will be allocated a peptide by the course coordinator. All allocations will be final.
1x 0:00 7:00
24/05/2021 Peptide mediators poste
https:
mit.instructure.com/courses/79108/assignments/ XXXXXXXXXX/3
Please note that the 'Groups' function on Canvas is only being used to manage the selection/allocation of students to a specified peptide. This is an individual
assignment, you are NOT expected to work with the other students who have selected
een allocated the same peptide as you.
Once you have selected your peptide, you need to do the following:
1) Research your peptide. Your research should focus on two main areas:
a) The physiology and pharmacology of your peptide (this includes the peptide production, physiological action, and termination of action). When researching the
physiology and pharmacology of your peptide you need to focus on the core pharmacology concepts related to peptide signalling that we have discussed in class.
Key things to consider include:
How is your peptide synthesized?
How is your peptide released? (e.g. What stimulates/inhibits release of your peptide?)
What receptors does your peptide interact with? What type of receptors are these?
What are the consequences of that interaction? (e.g. Is your peptide an agonist, antagonist, or allosteric modulator? What signalling pathways are affected when
your peptide binds to these receptors?)
How are the actions of your peptide terminated?
) The role of your peptide in regulating feeding and satiety. Does your peptide increase or decrease food intake?
Your primary source for research should be peer-reviewed biomedical science literature which you can search for using PubMed (https:
www.ncbi.nlm.nih.gov/pubmed
(https:
www.ncbi.nlm.nih.gov/pubmed/) ).
Note: The role of peptide mediators in regulating appetite is an area of active cu
ent research, and much of our knowledge in this field is very new. You should not expect to
find evidence from clinical studies conducted in humans. You will need to consider information from other types of research such as experimental preclinical studies, animal
models, cultured cells, bioinformatics, etc. These different types of research all make important contributions to drug development.
 
2) After researching your peptide, decide which part of that peptide pathway you will target to create a theoretical drug that will reduce food intake.
a) Which part of the peptide pathway will you target?
) How will your drug affect that target? Remember to use your core pharmacology concepts to help you decide this.
 
3) Create a name for your new drug.
 
4) Prepare a 1 page poster (A4 size) advertising your new drug. The design of your poster is up to you, however your poster must include the following required elements:
a) The name of your new drug (be creative!).
) A
ief description of the peptide pathway your drug acts on, and how this peptide affects food intake.
c) An explanation of the mechanism of action for your drug. Use a flow chart or diagram to help explain this.
d) A catchy marketing slogan to advertise your drug. (For the purposes of this exercise, we will disregard the normal regulations that govern the marketing of
pharmaceuticals in Australia!).
e) Reference information. You can choose your prefe
ed referencing style, and where you place this information on your poster (although it must be on the same page
as the poster, not on the back). There is no minimum number of references.
 
https:
www.ncbi.nlm.nih.gov/pubmed
24/05/2021 Peptide mediators poste
https:
mit.instructure.com/courses/79108/assignments/ XXXXXXXXXX/3
Total points: 100
Peptide mediators poste
Criteria Ratings Pts
50 pts
20 pts
20 pts
10 pts
5) Submit your poster (as a PDF) via Canvas by 9am Monday May 31 (week 13).
 
RMIT Electronic submission of work for assessment
I declare that in submitting all work for this assessment I have read, understood and agree to the content and expectations of the Assessment declaration
(https:
www.rmit.edu.au/students/student-essentials/assessment-and-exams/assessment/assessment-declaration) .
 
Learning Outcomes
Research the physiological pathway of a specific peptide mediator.
Apply your knowledge of pharmacology to design a theoretical drug that interacts with this peptide pathway to produce a desired biological effect.
Communicate information about your peptide pathway and theoretical drug in a clear, engaging, and scientifically accurate manner.
 
Assessment criteria and feedback mode: 
Your assignment will be assessed and feedback will be provided via Canvas. The ru
ic for this assessment can be found below.
 
st
Scientific
accuracy
50 Pts
100%
Peptide pathway information is
very clear, comprehensive and
accurate. Mechanism of action is
very clear and that displays an
excellent understanding of the
pharmacology involved.
40 Pts
80%
Peptide pathway information is
clear, comprehensive and
accurate. Mechanism of action
is very clear and displays a very
good understanding of the
pharmacology involved.
30 Pts
60%
Peptide pathway
information is mostly clea
and accurate. Mechanism
of action is clear and
displays good
understanding of the
pharmacology involved.
20 Pts
40%
Peptide
pathway
information is
sometimes
inaccurate.
Mechanism of
action is
unclear.
10 Pts
20%
Peptide pathway
information has
many inaccuracies.
Mechanism of
action is poorly
communicated o
inaccurate.
0 Pts
No marks
Peptide pathway
information has
many inaccuracies.
Mechanism of
action is poorly
communicated o
inaccurate.
Professional
expression
and use of
language
20 Pts
100%
Writing is clear, concise and
informative throughout.
Professional style and
expression used consistently
with no e
ors in spelling,
punctuation, or grammar.
16 Pts
80%
Writing is generally clea
and informative.
Professional style and
expression used
consistently Few mino
e
ors in spelling,
punctuation, or grammar.
12 Pts
60%
Writing is generally
clear. Mostly
professional style
and expression.
Some e
ors in
spelling,
punctuation, o
grammar.
8 Pts
40%
Writing is sometimes
unclear. Some use of
professional style and
expression. Multiple
e
ors in spelling,
punctuation, o
grammar.
4 Pts
20%
Writing is often unclear,
with limited use of
professional style and
expression. Multiple
e
ors in spelling,
punctuation, o
grammar.
0 Pts
No marks
Writing is very unclear,
with limited use of
professional style and
expression. Many
e
ors in spelling,
punctuation, o
grammar.
Design,
organization
and layout
20 Pts
100%
Poster has a clea
organization, with
excellent design and
layout. The pictures
and graphics are clea
and highly relevant.
16 Pts
80%
Poster has a clea
organization, with very
good design and
layout. The pictures
and graphics are clea
and relevant.
12 Pts
60%
Poster has a clea
organization with
generally good design
and layout. The pictures
and graphics are mostly
clear and relevant.
8 Pts
40%
Poster lacks a clea
organization. Design and
layout are unclear o
confusing. The pictures and
graphics are sometimes
unclear or i
elevant.
4 Pts
20%
Poster lacks
organization. Design and
layout are unclear o
confusing. The pictures
and graphics are often
unclear or i
elevant.
0 Pts
No marks
Poster lacks
organization. Design
and layout are unclea
or confusing. The
pictures and graphics
are unclear or i
elevant.
Content 10 Pts
100%
All required elements are
present, and clearly and
comprehensively
communicated.
8 Pts
80%
All required elements
are present and
clearly
communicated.
6 Pts
60%
Most required
elements are present
and clearly
communicated.
4 Pts
40%
Few of the required
elements are present and
clearly communicated.
2 Pts
20%
One (or more)
equired elements is
missing and/o
inco
ect.
0 Pts
No marks
Most or all of the
equired elements are
missing and/o
inco
ect.
https:
www.rmit.edu.au/students/student-essentials/assessment-and-exams/assessment/assessment-declaration