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CASE SCENARIO FOR THE LABORATORY REPORT XXXXXXXXXXAgo: 57) 00s: 7 Gender: ‘specimen Type: AC LEFT BREAST Clinical Details: 0 6 mm, Disiance from ripple 48 mm. Coordinates 5 Left Mass-poorty...

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CASE SCENARIO FOR THE LABORATORY REPORT
XXXXXXXXXXAgo: 57)
00s:
7
Gender:
‘specimen Type:
AC LEFT BREAST
Clinical Details:
0 6 mm, Disiance from ripple 48 mm. Coordinates 5
Left Mass-poorty defined. Si
FoF on size 6 mm. Multifocal lobe. Axila normal.
Macroscopic Description:
A LEFT BREAST:
EE issue measuring 15,15 and 14mm erg
‘AT Fa. Breast core protocol. All taken.
Microscopic Descri
oe mopey nfilated by grade 2 invasive ductal carcinoma with focal high grade DCIS
eceptors o follow.
Hormone Receptors:
ER: Alred Score 818
PR: Allred Score 418,
HER?: Score 2+, FISH a!
R2 (ERBB2) Gene Amplification
Weak Posiive (weak staining in 20% of tumour ces)
waited
FISH Testing - HE
Tissue Type: Breast
20 Tumour Calls Assesse
HER2/CEP17 Ratio: 1.13
Mean CEP17/Cell: 2.00
Mean HER2 Gene/Cell: 2.25
Rosult: HER2 Gene is NEGATIVE
d (BioView)
ctal carcinoma. BS
Final Diagnosi
Left
east, core biopsy: - IMV2SH® du

Questions to be answered:
1

SBU
criteria required for specimen
EST1892
dent the patient dentifrs and discuss the.
acceptance.
Drecuss the importance of cinical information in this case.
Discuss the importance of screening programmes in tis cas:
and why do they exist?
Explain the hormone receptors res
Whats the significance of HER? for tis patient?
What other tests/ICC that can be used for
east cancer diagnosis?
What would be the suggested treatment considering the results?
what does it involved
including HER?.
Answered 2 days After Dec 08, 2022

Solution

Dr. Sulabh answered on Dec 11 2022
33 Votes
Breast Cancer Study1
BREAST CANCER STUDY
Name of the Student
Course
Teacher Name
Name of the college or University
Date
Assignment
BREAST CANCER STUDY
1. The case study includes the analysis and screening of a female patient aged 57 years diagnosed with the condition of
east cancer. The identifier in this study is the analysis of the left
east lobe of this patient indicated with the presence of fi
ous fatty tissue in the left
east lobe in the imaging report. The length of the fi
ous tumor in the left
east of the female patient is around 15mm in length. The criterion required for the acceptance of the tissue in the category of
east cancer is that it should fall in any grade like grade I, grade II, grade III, and grade IV. The analysis revealed that it is a grade II
east cancer. The imaging results reveal that the size of the lesion formed on the
east is of size 6mm. In-situ ductal carcinoma is a cancer of the milk glands present in the
easts of a female. The epithelial cells line the internal lining of the milk ducts which secrete milk in the
easts. During the condition of in situ ductal carcinoma, there is an abnormal growth and proliferation of the epithelial cells lining the milk ducts in the
east tissue. The symptom of this carcinoma includes the formation of hard tissue lumps in the
east region and it is associated with mutations in the BRCA gene. A complete history of the patient including age, sex, demography, and history is required while preparing a medical record of the patient undergoing the treatment procedure. 
       The HER2 receptor is present on the locus of chromosome 17 in humans. During the activation of the cellular signaling response, there is a process of pairing of the different EGFR (epidermal growth factor receptors) present on the surface of the cells being studied. During the analysis of different grades of
east cancer, there is a calculation of the ratio of HER2/CEP 17. CEP17 is called centromere loci copy. If this ratio is high then there are more chances of the occu
ence of the cancer state. Trastuzumab therapy is prescribed for patients who have a high-grade cancer with a high ratio of HER2/CEP17 (Stocker et al., 2016). 
 After 3-dimensional scanning and X-ray analysis, there is a visualization of a white tissue calcification in the
east region. The cancer-invasive cells present in the
east region are removed through the technique of lumpectomy whereas the surgical technique of mastectomy removes the entire cancer-prone tissue present in the
east cancer region. External powerful internal beam radiations are also used for treating cancer as the high-intensity beam is concentrated on the cancerous tissue leading to the death of the cancer cells (Cleveland Clinic, 2022). However, there are side effects of the hormone therapy, radiation and chemotherapy prescribed to the patients like feeling anxious, tired, fatigue, redness, soreness, and inflammation in the affected area of the
easts undergoing the therapy (Cleveland Clinic, 2022). 
The
east region consists of tissue, blood vessels, and lymph which drain the fatty acid molecules. A swelling is observed in the node regions of the
east during the occu
ence of
east cancer disease. During the transition from stage 1 to stage 4 the tumor moves and migrates from the
east tissue toward the other parts of the human body including the lymph node infection also. Further a grading scale is studied after measuring the size of the tumor obtained from the sample under investigation (InfoHealth, 2016). 
There are different types of
east cancer as indicated and discussed below:
i. Lumen-type
east cancer of type A which is negative for the HER2 receptor and positive for the estrogen and the progesterone receptor. The movement and migration of these cancer cells take place slowly from the region of origin to the other parts of the human body.
ii. Lumen-type
east cancer of type B which is negative or positive for the HER2 receptor and positive for both the estrogen receptor and the progesterone receptor. 
iii. The next is a type in which the
east tissue sample is negative for the estrogen receptor, progesterone receptor, and for HER2 receptor. The BRCA gene which is a cancer-related gene is also negative in these tissue samples. 
iv. HER2-activated type of
east cancer in which there are more number of receptors expressed on the surface of the tissue samples and there is negative testing for the estrogen and the progesterone...
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