do
EST 1892
LSBU
CASE SCENARIO FOR THE LABORATORY REPORT
XXXXXXXXXX
Gender: ZTHEINI Be. 7)
Spocimen Type:
A: LEFT BREAST
Clinical etait:
Cot Mast-pooty defined. Size 8x8 mm Distance
. ori 48m oo
Lesion size 6 mm. Multifocal lobe. Axilla normal. om SE
Macroscopic Description:
A. LEFT BREAST:
3 cores of fi
ofatty tissue measuring 15, 15 and 14 mm in length.
A1 F3. Breast core protocol. Al taken.
Microscopic Description:
Core biopsy infiltrated by grade 2 invasive ductal carcinoma with focal high grace ocis,
eceptors to follow.
Hormone Receptors:
ER: Allred Score 8/8
PR: Allred Score 4/8, Weak Positive
HER2: Score 2+, FISH awaited
(weak staining in 20% of tumour cells)
FISH Testing - HER2 (ERBB2) Gene Amplification
Tissue Type: Breast ;
20 Tumour Cells Assessed (BioView)
HER2/CEP17 Ratio: 1.13
Mean CEP17/Cell: 2.00 a
Mean HER2 Gene/Cell: 2.2
Result; HER2 Gene is NEGATIVE
Final Diagnosis:
BSD
Left
east, core bi ductal carcinoma,
jopsy: - Invasive
LSBU
Questions to be answered:
\
1
on
Noosa
Identify the patient identifiers and discuss the criteria required for specimen
acceptance.
Discuss the importance of clinical information in this case.
Discuss the importance of screening programmes in this case, what does it involved
and why do they exist?
Explain the hormone receptors result including HER2.
What is the significance of HERZ for this patient?
What other tests/ICC that can be used for
east cancer diagnosis?
What would be the suggested treatment considering the results?
EST 1892
LSBU
CASE SCENARIO FOR THE LABORATORY REPORT
XXXXXXXXXX
Gender: ZTHENSS Be: OT)
Specimen Type:
A: LEFT BREAST
Clinical Details:
Left Mass-poorly defined. Size 8 x 6 mm. Distance
x from nipple 46 mm. Coordina
Lesion size 6 mm. Multifocal lobe. Axilla normal. td Soordinstes Bs.
Macroscopic Description:
A. LEFT BREAST:
3 cores of fi
ofatty tissue measuring 15, 15 and 14 mm in length.
A1 F3. Breast core protocol. Al taken.
Microscopic Description:
Core biopsy infiltrated by grade 2 invasive ductal carcinoma with focal high grade ocis,
eceptors to follow.
Hormone Receptors:
ER: Alired Score 8/8
PR: Allred Score 4/8, Weak Positive
HER2: Score 2+, FISH awaited
(weak staining in 20% of tumour cells)
FISH Testing - HER2 (ERBB2) Gene Amplification
Tissue Type: Breast 3
20 Tumour Cells Assessed (BioView)
HER2/CEP17 Ratio: 1.13
Mean CEP17/Cell: 2.00 i
Mean HER2 Gene/Cell: 2.2
Result; HER2 Gene is NEGATIVE
Final Diagnosis:
BSD
Left
east, core bi juctal carcinoma,
jopsy: - Invasive dt
EST 1892
LSBU
CASE SCENARIO FOR THE LABORATORY REPORT
XXXXXXXXXX
Gender: ZTHENSS Be: OT)
Specimen Type:
A: LEFT BREAST
Clinical Details:
Left Mass-poorly defined. Size 8 x 6 mm. Distance
x from nipple 46 mm. Coordina
Lesion size 6 mm. Multifocal lobe. Axilla normal. td Soordinstes Bs.
Macroscopic Description:
A. LEFT BREAST:
3 cores of fi
ofatty tissue measuring 15, 15 and 14 mm in length.
A1 F3. Breast core protocol. Al taken.
Microscopic Description:
Core biopsy infiltrated by grade 2 invasive ductal carcinoma with focal high grade ocis,
eceptors to follow.
Hormone Receptors:
ER: Alired Score 8/8
PR: Allred Score 4/8, Weak Positive
HER2: Score 2+, FISH awaited
(weak staining in 20% of tumour cells)
FISH Testing - HER2 (ERBB2) Gene Amplification
Tissue Type: Breast 3
20 Tumour Cells Assessed (BioView)
HER2/CEP17 Ratio: 1.13
Mean CEP17/Cell: 2.00 i
Mean HER2 Gene/Cell: 2.2
Result; HER2 Gene is NEGATIVE
Final Diagnosis:
BSD
Left
east, core bi juctal carcinoma,
jopsy: - Invasive dt