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10/7/22, 11:03 PM Literature Review https://rmit.instructure.com/courses/96352/assignments/ XXXXXXXXXX/4 Literature Review Due 27 Sep by 23:59 Points 30 Submitting a file upload Available 19...

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10/7/22, 11:03 PM Literature Review
https:
mit.instructure.com/courses/96352/assignments/ XXXXXXXXXX/4
Literature Review
Due 27 Sep by 23:59 Points 30 Submitting a file upload
Available 19 Aug at 0: XXXXXXXXXXSep at 23:59
This assignment was locked 27 Sep at 23:59.
Course Title: Functional Genomics and Proteomics
Course Title: BIOL2267/BIOL2332
Literature Review
Overview:
This literature review assignment is to provide an opportunity for students to develop writing and
critical view of the literature on a topic of their choice in consultant with the course coordinato
Details:
Topics: Any topic on the application of functional genomics and/or proteomics in any filed, such as
the use of functional genomics in cancer research.
Length: XXXXXXXXXXwords for UG students and XXXXXXXXXXwords for PG students (not including
eferences), tables and figures (if any). Please note that 10% of marks will be deducted if the
number of words written in your review is 10% less than or 25% longer than required. The
literature review should consists of an Introduction, a main body and a conclusion
Total marks available are 30
Assessment due date: 27 September 2022
Please submit your literature review onto CANVAS by the due date. You can submit a single
Word Document/PDF file.
Guide
A literature review is an exploration of the published literature on a particular topic. Sources of the
published literature may include scholarly journal articles, books, government reports, and othe
sources. It has an introduction, a body and a conclusion.
Title (1 mark): A concise title of no more than 15 words
Introduction (5 marks)
Provide background on the topic and its importance, and state your objective.
Body (15 marks)
- Provide a description, summary and evaluation of each source and combine them into a logical
whole.
10/7/22, 11:03 PM Literature Review
https:
mit.instructure.com/courses/96352/assignments/ XXXXXXXXXX/4
Literature review ru
ic
- Analyse and interpret the literature, do not just paraphrase them
- Use subheadings, create a logical structure of the review
Conclusion (5 marks)
Summarise the key findings, emphasise their significance and suggestions for future research.
References and language (4 mark)
- References cited in text must appear in the reference list and vice versa (except for the sources
when no author can be identified - these are cited in text and are not included in the reference list).
- Be consistent with the formatting style
-Clear and concise writing style.
-Appropriate use of scientific language.
Learning Objectives Assessed:
This assessment supports CLOs 1, 4, 5, 6 & 7
10/7/22, 11:03 PM Literature Review
https:
mit.instructure.com/courses/96352/assignments/ XXXXXXXXXX/4
Criteria Ratings Pts
1 pts
5 pts
15 pts
5 pts
Title
A concise title of no
more than 15 words
1 Pts
Very Good
The title is
concise and not
more than 15
words
0.63 Pts
Good
It is
understandable
ut not very
concise
0.25 Pts
Poo
It's too hard to
understand,
and too long
0 Pts
Fail
The title is totally
i
elevant to the
ody of the literature
Introduction
Provide background
on the topic and its
important, and state
your objective
5 Pts
Very good
Excellent topic
ackground and
its important and
the objective of
the review is
clearly stated
3 Pts
Good
Good background of
the topic and the
objective is clear.
There may be some
minor inaccuracies in
the information.
2 Pts
Poo
The background
and objective
are poorly
written and not
very relevant to
the topic
0 Pts
Fail
No
elevant
information
Body
- Provide a
description,
summary and
evaluation of each
source and combine
them into a logical
whole.
- Analyse and
interpret the
literature, do not just
paraphrase them
- The articles
eviewed are clearly
inter-related
- Use subheadings,
create a logical
structure of the
eview
15 Pts
Very Good
Information obtained from
each source are
exceptionally
communicated, combined
and analysed. The
structure is logical
organised and clear.
11.25 Pts
Good
Information are
organised,
interpreted and
communicated well.
Some statements
may contain mino
e
or.
5 Pts
Poo
The
literature
isn't
analysed
and most
are wrongly
interpreted.
0 Pts
Fail
No
elevant
information
Conclusion
Summarise the key
findings, emphasise
their significance and
suggestions fo
future research.
5 Pts
Very Good
Clear and logical
conclusions are drawn from
the scientific literature and
limitations are identified.
3.75 Pts
Good
Conclusions are
clear but may
contain some
gaps in logic.
1.25 Pts
Poo
Conclusions
contain
large gaps
in logic
0 Pts
Fail
No
conclusion
or it's
i
elevant
10/7/22, 11:03 PM Literature Review
https:
mit.instructure.com/courses/96352/assignments/ XXXXXXXXXX/4
Total points: 30
Criteria Ratings Pts
4 pts
References
- References cited in
text must appear in
the reference list and
vice versa (except
for the sources when
no author can be
identified - these are
cited in text and are
not included in the
eference list).
- Be consistent with
the formatting style
- Write in a clear and
concise way
-Appropriate use of
scientific language
4 Pts
Very Good
Information is
co
ectly referenced
–in-text and in
eference list. The
formatting style is
used consistently
through the review.
The review is well
written and concise
and scientific
language is used
well.
3 Pts
Good
Missing one o
two references
or the formatting
style is not
consistently
used. Writing
style is
easonable,
although some
grammatical o
scientific e
ors.
1 Pts
Poo
Many references
cited in text but not
appear in the
eference list and
different formatting
styles were used.
The writing is very
unclear and the use
of scientific terms is
not appropriate.
0 Pts
Fail
No
eference
list. Writing
is poor o
only
partially
completed.
Poorly
used
scientific
terms.
Answered 2 days After Oct 07, 2022

Solution

Dr Shweta answered on Oct 10 2022
53 Votes
Title: Application of Functional Genomics in the field of cancer and potential cancer drugs targets.
Introduction:
Functional genomics is the
anch of biology which deals with the study of diverse regions of genome and their role in varied biological processes. In this the location of different genes and their characteristic functions are studied and a list of contender genes that are responsible for regulating different biological networks are identified. With the help of functional genomics, it is possible to identify different components of a biological system and how they interact together to ca
y out a particular biological process. It helps us to understand the complete pathway of gene expression for the production of a specific phenotype. It deals with the information of DNA in genomics, epigenomics, information of RNA in transcriptomics, information of protein in proteomics and details about metabolite in metabolomics hence links the genotype to phenotype [1]. Functional genomics employs different approaches to evaluate the location and function of gene using the high quality and sensitive cellular, genetic and molecular technologies. Functional genomics utilizes the next-generation gene, ‘omics’ data sets and epigenome modification tools to agitate the genes of interest. Using functional genomics, researchers recognized thousands of disease-linked polymorphisms, the connective gene expression and the underlying functional changes in the human population. For example; Many diseases, such as diabetes, autoimmune diseases, cancer, and neurological disorders, are caused by a dysregulation of a complex interplay of genes. [2]. Among its various potential uses, this article is specifically related to the application of functional Genomics for the discovery of potential cancer drugs targets. Here, we discuss how cancer biologists utilizes the immeasurable potential of functional genomics to study all the activities of genetic loci and identify the potential drug targets.
Body:
Functional genomic researchers used the cell-culture experiments and genome-modifying technologies to understand the co
elation between genes and its controlling elements. Using these results, they can identify the potential proto-oncogenes and the targeted drug sites and helps in the designing of highly selective and potential cancer drugs [3]. Kabadi et al in 2020 [4] reported in their research paper that recently CRISPR-Cas systems are the widely used programmable tools for scanning of millions of genetic codes in DNA and for editing the genome. They are frequently used owing to their easy accessibility. The term CRISPR” is an acronym of “Clustered Regularly Interspaced Short Palindromic Repeats”, and is the foundation of CRISPR-Cas9 genome editing technology. It provides in-depth information to analyze the biological interaction between genes and the complete biological network. With the help of these information, accurate disease modeling and identification of potential drug targets becomes easier. It is believed that the involvement of functional genomic techniques into traditional drug production strategies accelerate the production of highly sensitive and accurate therapeutics. Likewise, Hailey et al in 2020 [5] mentioned in their research article that RNA interference technology is highly significant for the discovery and screening of potential cancer drug targets. They reported that using the advanced and highly sensitive loss-of-function (LOF) tools, analytical methods of RNA interference (RNAi), technology and small interfering RNA (siRNA)-guided mRNA dilapidation technology in-depth genetic screening of mammalian systems can be performed. These methods are capable of performing the endogenous processing of RNA and selective target suppression and hence geared up the production of various approved therapeutics for cancer. For instance, the
east cancer drug Herceptin that specifically targets the overexpressed HER-2 protein of tumors is also designed using these techniques. Chandrasekaran et al in 2022 [6] also reported about the evolving CRISPR associated system (Cas) tools which is based on the occu
ence of clusters of repeatedly interspaced small palindromic repeats. They mentioned that these advanced genomics techniques and proteomics tools transformed the field of cancer drug discovery and identification of their potential targets. The CRISPR-Cas tool provides in-depth insight for several gene therapies, cell culture-based assessments thar are basically employed to screen the potential drug targets. Along with this, due to its sensitivity towards biomarker identification and specific target genes, it also helps in the development of new disease models, understanding of the drug resistance processes and the evaluation of efficiency of a newly designed drug. The CRISPR-Cas-mediated gene editing tool has significant applicability in the field of efficient drug screening, drug designing specifically for the inheritable mendelian syndromes, cancer and for the development of different cell or gene based anticancer...
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