Jenny, a 6-year-old child who has been
raised in a germ-free environment from birth, is a victim of...

Question

Jenny, a 6-year-old child who has been
raised in a germ-free environment from birth, is a victim of one of the most
severe examples of an abnormal immune system. Jenny also suffers from cancer
caused by the Epstein-Barr virus. Relative to this case: 

(a) What is the usual fate of children with
Jenny’s condition and similar circumstances if no treatment is attempted? 

(b) Why is Jenny’s brother chosen as the
hematopoietic stem cell donor? 

(c) Why is her physician planning to use
umbilical cord blood as a source of stem cells for transplant if her brother’s
stem cells fail (what are the hoped-for results)? 

(d) Attempt to explain Jenny’s cancer. 

(e) What similarities and dissimilarities
exist between Jenny’s illness and AIDS?

Dr. Saloni · Accepted Answer

1
Case Study of Jenny
Answer a
Jenny is experiencing SCID (severe combined immunodeficiency disease), a condition in which B and T cells do not develop. At best, only a few lymphocytes are observable. This disease has a fatal outcome if left unaddressed (Al-Mousa et al. 2018).
 
Answer b
Jenny's brother is the strongest antigenic match because they are both born to the same father and mother. Biological brothers and sisters are usually chosen as donors because they impose lower potential dangers of GVHD (graft-versus-host disease) as well as other transplant-related consequences when compared to unrelated donors. In exceptional cases, a child may be regarded as a potential donor for an elderly brother or sister, parents,

Jenny, a 6-year-old child who has been raised in a germ-free environment from birth, is a victim of one of the most severe examples of an abnormal immune system. Jenny also suffers from cancer caused...

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