Hypersensitivity and types of hypersensitivity?

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David · Accepted Answer

Hypersensitivity is when an otherwise healthy immune system has an undesirable 
exaggerated response to a foreign substance (or perceived foreign substance) that damages the 
body’s own cells.
Type I Hypersensitivity is triggered by an innocuous foreign substance (like dust, pollen 
or animal dander) that would cause no problems in the majority of people. The antigen 
simultaneously binds more than one membrane bound IgE on a mast cell (or basophil). This 
process, called Crosslinking, triggers the release of mast cell granules full of histamine.  
Histamine then goes on to signal the various changes associated with allergies similar to how it 
functions during acute inflammation. This allergic reaction happens almost instantly and the 
symptoms can become evident within minutes. This is possible because the mast cells are Pre-
Sensitized to the innocuous substance which means they have pre-formed membrane bound IgE 
that recognizes the particular innocuous antigen.

Hypersensitivity and types of hypersensitivity?

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