25/10/2020 Clinical Biochem and Renal Function and Blood Lipid Assessment
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Clinical Biochem and Renal Function and Blood Lipid As‐
sessment
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BIOL1181: Clinical Biochem and Renal Function and Blood Lipid Assignment - part of
Assessment Task 1: Assignments
Weighting: 20% final mark (word count 800 words)
Due Date: Friday 30th October 23:59 DEFERRED to 23:59 Sunday 1st Novembe
Overview:
In this assignment you will be asked to demonstrate your understanding and interpretive skills
that relate to what you have learned in the Clinical Biochemistry module. Whilst some of you
are not Lab Med students, the skills that you learn are also important for you - particularly if
you are going to look at physiology or pharmacology in the future as these skills are similar to
those that you will require in those courses.
Discussion with your colleagues is encouraged. By discussing/teaching concepts with/to
your colleagues, then it assists you to understand. See this link
(https:
effectiviology.com/protege-effect-learn-by-teaching/) . However, you must submit you
own work.
This assignment will be submitted via Turnitin, a software that checks for similarity in words.
This will give you feedback on the percentage similarity - however this can take up to 24
hours. Please submit it early to allow time for you to amend any parts that may have been
copied in e
or. The reason we do this is to make sure that you really do understand what you
are writing - if you can't put it in your own words, then you really don't understand it.
RMIT Electronic Submission of work for assessment
I declare that in submitting all work for this assessment I have read, understood and agree to
the content and expectations of the assessment declaration
(https:
www.rmit.edu.au/students/student-essentials/assessment-and-
exams/assessment/assessment-declaration) .
Learning Outcomes:
The Course Learning Outcomes assessed by this assignment are:
https:
effectiviology.com/protege-effect-learn-by-teaching
https:
www.rmit.edu.au/students/student-essentials/assessment-and-exams/assessment/assessment-declaration
Taksh Patel
25/10/2020 Clinical Biochem and Renal Function and Blood Lipid Assessment
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CLO1: Explain key concepts in biochemistry and molecular biology
CLO2: Describe and explain the principles and fundamental concepts of biochemistry and
molecular biology with a focus on DNA Technologies, Hormones and Biosignaling,,
Metabolism, Metabolomics and Clinical Biochemistry
Assessment Criteria:
You will be assessed on your ability to:
Answer questions succinctly (800 words +/- 10%)
Provide scientific justification for your answers in a rational and logical manne
Problem solving - provide the appropriate solution to the problem
Feedback and Grades:
Feedback on your assignment and your grade will be released via the 'Grades' tab on the
menu at the left hand side of the page within 2 weeks of the due date.
If you have any problems with this assignment, please contact the Course
Coordinator XXXXXXXXXX (mailto: XXXXXXXXXX) for assistance.
To help you understand what you need to answer CHECK THE RUBRIC ATTACHED to this
assignment - don't forget to double check this before you submit.
HERE ARE THE CASE STUDIES BIOL1181 Clin Biochem Case Studies.pdf
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25/10/2020 Clinical Biochem and Renal Function and Blood Lipid Assessment
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Case Study Clinical Biochemistry
Page 1 of 2 ZOOM
CB-1 Clinical biochemistry cases;
Case-1
20-year-old female with Type I Diabetes Mellitus presents to the accident and emergen
department, giving a 2-day history of vomiting and abdomen pain. She is drowsy, and
is deep and rapid. There is a distinctive smell from her
eath. Initial biochemistry resu
follows:
Arterial blood gas
pH XXXXXXXXXX)
PCO2 8 mm Hg XXXXXXXXXX)
PO2 92 mm Hg XXXXXXXXXX)
HCO3 7 mmol/L (23-33)
Plasma
Sodium XXXXXXXXXXmmol/L XXXXXXXXXX)
Potassium 7.0 mmol/L XXXXXXXXXX)
Chloride 93 mmol/L XXXXXXXXXX)
Urea 10.1 mmol/L XXXXXXXXXX)
Creatinine 0.18 mmol/L XXXXXXXXXX)
Glucose XXXXXXXXXXmmol/L XXXXXXXXXX)
Urine dip stick
Glucose +++
25/10/2020 Clinical Biochem and Renal Function and Blood Lipid Assessment
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Criteria Ratings Pts
6.0 pts
12.0 pts
18.0 pts
3.0 pts
21.0 pts
12.0 pts
Interp Clin
Features
Interpretation of
clinical features
(6 marks)
6.0 Pts
Exemplary
All signs &
symptoms defined
&/or explained in
detail. All
co
elated to
pathophysiological
processes.
4.0 Pts
Adequate
All signs &
symptoms defined
&/or explained.
However, the
co
elation to the
pathophysiological
processes was
unclear.
2.0 Pts
Needs more work
No definition o
explanation for signs
& symptoms. No
co
elation to any
suitable
pathophysiological
process. Signs and
symptoms only
estated.
0.0 Pts
Unsatisfactory
No definition o
explanation for signs
& symptoms. No
co
elation to any
suitable
pathophysiological
process. Signs and
symptoms only
estated.
Eval & Interp
Lab Results
Evaluation and
interpretation of
laboratory
esults
(12 marks)
12.0 Pts
Exemplary
All laboratory results
discussed in detail and
with clear analytical and
logical thought
processes.
8.0 Pts
Adequate
All laboratory results
were discussed
however, key results
have been
misinterpreted.
4.0 Pts
Needs more work
Laboratory results
discussed, howeve
key results were
omitted from the
analysis.
0.0 Pts
Unsatisfactory
No discussion
of laboratory
esults.
Laboratory
esults only
estated.
Data Analysis
Analysis of Data
leading to
Provisional
diagnosis (PD)
(18 marks)
18.0 Pts
Exemplary
PD thoroughly discussed
demonstrating
oad and
coherent knowledge
throughout case with
elevant justification.
12.0 Pts
Adequate
PD discussed throughout
case with justification fo
the selection, however,
elevant laboratory o
clinical data has been
omitted.
6.0 Pts
Needs more
work
Analysis of
the data is
attempted
ut is
incomplete o
off-track.
0.0 Pts
Unsatisfactory
No relevant
analysis o
justification.
PD
Co
ect
Provisional
Diagnosis
selected
(3 marks)
3.0 Pts
Exemplary
Co
ect PD
selected
2.0 Pts
Adequate
A relevant diagnosis was selected for the
PD.
0.0 Pts
Unsatisfactory
Inco
ect PD was
selected
Answers to
Questions
Co
ect answe
provided for the
given questions
(21)
21.0 Pts
Exemplary
All the questions
(including
calculations) are
answered and
discussion
co
ectly with
adequate details
14.0 Pts
Adequate
All the questions
(including calculations) are
answered co
ectly,
however discussions are
inadequate with lacking
attention to the details
7.0 Pts
Needs more work
Some questions are
answered, with
flaws in accuracy,
lack of attention to
the details,
inadequate
discussion
0.0 Pts
Unsatisfactory
No question is
answered
co
ectly
Aetiology and
Pathophys
Aetiology &
pathophysiology
of PD (12
marks)
12.0 Pts
Exemplary
Aetiology &
pathophysiology
of PD
accurately,
concisely and
logically
described.
8.0 Pts
Adequate
Aetiology & pathophysiology
of PD described however,
key concepts are described
unclearly, or the information
presented is repetitive.
4.0 Pts
Needs more
work
Aetiology &
pathophysiology
of PD described
ut significant
features have
een omitted.
0.0 Pts
Unsatisfactory
Aetiology &
pathophysiology of
PD was not
described or an
unrelated diagnosis
was described.
25/10/2020 Clinical Biochem and Renal Function and Blood Lipid Assessment
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Total points: 84.0
Criteria Ratings Pts
12.0 pts
Communication
Communication
Style (12 marks)
12.0 Pts
Exemplary
Well-developed
communication
skills by effectively
communicating
scientific concepts
clearly, concisely
and logically. 800
words ± 10% (fo
the two cases
combined)
(excluding tables
and figures)
8.0 Pts
Adequate
Intermediate
communication
skills demonstrated
y a mixture of
styles in the various
sections of this case
study. 11-15% ove
or under 800 words
(for the two cases
combined)
(excluding tables
and figures)
4.0 Pts
Needs more work
Low level
communication skills
demonstrated but
sections with illogical
flow and/or long-
winded and circuitous
explanations. 16-20%
over or under 800
words (for the two
cases combined)
(excluding tables and
figures)
0.0 Pts
Unsatisfactory
Poo
no
communication
skills demonstrated
y illogical flow
and/or long-winded
and circuitous
explanations. 20%
over or under 800
words (for the two
cases combined)
(excluding tables
and figures)
RMIT Classification: Trusted
CB-1 Clinical biochemistry cases;
Case-1
20-year-old female with Type I Diabetes Mellitus presents to the accident and emergency
department, giving a 2-day history of vomiting and abdomen pain. She is drowsy, and her
eathing
is deep and rapid. There is a distinctive smell from her
eath. Initial biochemistry results are as
follows:
Arterial blood gas
pH XXXXXXXXXX)
PCO2 8 mm Hg (35-45)
PO2 92 mm Hg XXXXXXXXXX)
HCO3 7 mmol/L (23-33)
Plasma
Sodium XXXXXXXXXXmmol/L XXXXXXXXXX)
Potassium 7.0 mmol/L XXXXXXXXXX)
Chloride 93 mmol/L XXXXXXXXXX)
Urea 10.1 mmol/L XXXXXXXXXX)
Creatinine 0.18 mmol/L XXXXXXXXXX)
Glucose XXXXXXXXXXmmol/L XXXXXXXXXX)
Urine dip stick
Glucose +++
Ketones +++
1. Describe the acid base distu
ance.
2. Calculate the anion gap and comment on its significance.
3. Calculate the osmolality and comment on its significance.
4. List two potential reasons for the raised potassium result.
5. Interpret the pathology results and suggest a provisional diagnosis.
RMIT Classification: Trusted
Case-2
A 55-year-old male, presented with chest heaviness, increased frequency of urination with the
history of hypertension. His lifestyle is very sedentary and in physical examination he showed to be
obese (height 165 cm, weight 102 kg, BMI of 37.5 kg/m2). Biochemistry results are as follows:
Plasma XXXXXXXXXXResults XXXXXXXXXXReference Intervals
Sodium XXXXXXXXXXmmol/L XXXXXXXXXX)
Potassium 5.0 mmol/L XXXXXXXXXX)
Chloride 91 mmol/L XXXXXXXXXX)
Urea 31.2 mmol/L XXXXXXXXXX)
Creatinine 2.8 mmol/L XXXXXXXXXX)
Glucose XXXXXXXXXXmmol/L XXXXXXXXXX)
Triglyceride XXXXXXXXXXmmol/L (<2.0)
Total-Chol XXXXXXXXXXmmol/L (<4.0)
LDL-Chol XXXXXXXXXXmmol/L (<2.0)
HDL-Chol XXXXXXXXXXmmol/L (≥1.0)
AST XXXXXXXXXX65 U/L XXXXXXXXXX –