Example Modification Table Modification Location Effect on...

Question

Example Modification Table
    Modification
    Location
    Effect on Transcription
    Modifie
    Interprete
    H3K123 monometh
di/trimeth
    Promote
Gene Body
Promote
    Activation
Repression and Alt splicing
Activation
    Fake1 and many proteins containing Stupid domain
????
Fake1 complexed with Real1
    HAT456 acetylates region
HP1 binds this modification
Stabilizes Mediator, blocks H3K789 methylation.
    H3K133 mono/dimeth
trimeth
    Promote
3’UTR
Promote
    Repression
Activation
Activation by Elongation
    Whodat and Whodat2
Whatsit Complex
????
    DNMT99 binds and methylates DNA
????
Something stabilizes RNA Pol, unknown
Epigenetics in Health and Disease Book by Igor Kovalchuk and Olga Kovalchuk (2012)
You are going to build a group summary of each modification listed in these two chapters 4 and 5 (in Table format). Include information on the effect (including where in the gene the modification has the effect) and any mechanisms that appear to be known. Of KEY IMPORTANCE are any proteins that interpret the modification and actually
ing about an effect. Order them however makes the most sense to you. Post your final group summary on the Modification Summary general discussion board when your group is finished (on Wednesday). An example table is posted below for your reference.
SPECIFIC READING INSTRUCTIONS - In chapter 4, skip the entire section on "DNA Adenine Methytransferase (DAM)." Begin again with Eukaryotic Methylation and end at "Cytosine Methylation in Plants." (We will not be focusing on plants in this course.)
In chapter 5, read from the beginning and stop at the part titled "Patterns of Histone . . . Interphase Nucleus." The information on patterns of acetylation in the nuclear architecture model is ga
led and a bit too contradictory for my tastes, so I elected to skip this (along with the plant portion once again).
Chapter 4
DNA methyltransferases, also called MTases
cell cycle-regulated methylase (CcrM)
DNA cytosine methyltransferase (Dcm)
de novo methyltransferases
De novo DNA methylation
Chapter 5
H3K9me and H3K9me2
Histone ubiquitination
Histone phosphorylation
Histone methylation/demethylation

example-modification-table1-s2bklld2.docx

Malvika · Accepted Answer

45937
Group Summary of Modification
Chapter 4
	S. No.
	Enzyme Modification
	Location of Effect
	Effect on Transcription
	Interpreter
	1
	DNA methyltransferases
	Regulatory regions of the gene 
	Loss of methylation on DNA
	Loss of viability in early embryonic stages 
	2
	Cell cycle-regulated methylase (ccrm)
	Cell cycle regulatory genes in proeteobacteria 
	Loss of methylation on DNA 
	Lack of proper cell division in the bacteria
	3
	DNA cytosine methyltransferase (dcm)
	Dcm gene on E. coli 
	Loss of methylation of Cytosine in E. coli 
	Some sites for cleavage by restriction endonuclease become resistant
	4
	Methyltransferases
	DNA, RNA, Histones 
	Loss of transfer of methyl groups to specific structures on DNA 
	Transcription,

Example Modification Table Modification Location Effect on Transcription Modifier Interpreter H3K123 monometh di/trimeth Promoter Gene Body Promoter Activation Repression and Alt splicing Activation...

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