A structured extended response XXXXXXXXXXwords). You will be allocated a drug and will need to write...

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A structured extended response XXXXXXXXXXwords). You will be allocated a drug and will need to write a structured extended response (500 – 600 words) discussing this drug and some key aspects of its pharmacology.Drug allocations will be published at the start of the assessment time, they will not be available prior to this time. You must write about your allocated drug.A series of structured questions to guide your response will be made available in the assignment instructions at the same time – please use these to guide your response.

Roopshikha · Accepted Answer

Part B:
A structured extended response (500 - 600 words).
Tramadol
(That is the drug I have been given)
These drugs are all listed as “CYP3A4 substrates” in the Australian Medicines Handbook (AMH).
Click on this page to access a copy of the TGA Product Information statement for a medication that contains your drug. These Product Information PDFs contain the pharmacokinetic data that you will need to answer the questions below. If your drug has a range of values for any of the pharmacokinetic data, then please use the average of these values for your calculations.
(I attached the copy of TGA as a attachment)
1. Briefly discuss whether the value of the volume of distribution applies to all routes of administration and comment on the distribution of your allocated drug. 
2. Calculate how long it takes to a) eliminate 95% of a single dose after absorption, and b) to reach a steady-state blood concentration after repeated dosing at regular half-life interval. Provide the equations used.
3. Calculate the systemic clearance of your allocated drug. Provide the equation used. Discuss whether this clearance value applies to all routes of administration.
4. Briefly discuss how administering your allocated drug with each of the medicines/foods below would affect the pharmacokinetics and risks of administering your allocated drug:
A. the antibiotic rifampicin, classified as a “potent inducer of CYP3A4” in the AMH; 
B. the antibiotic ketonazole, classified as a “potent inhibitor of CYP3A4” in the AMH. 
C. the herbal medicine St John’s wort, classified as an “inducer of CYP3A4” in the AMH;
D.

A structured extended response XXXXXXXXXXwords). You will be allocated a drug and will need to write a structured extended response (500 – 600 words) discussing this drug and some key aspects of its...

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