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1. Diseases are used to study the impact of dysregulated genes and cells. Use different genetic diseases (including cancer if you wish) from this course to provide specific examples of the following...

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1. Diseases are used to study the impact of dysregulated genes and cells. Use different genetic diseases (including cancer if you wish) from this course to provide specific examples of the following course topics:

(a) RNAi

(b) DNA methylation

(c) histone modification or chromatin proteins

Make sure to identify specific mechanisms from the diseases and link them back to the course content wherever possible.

1. Diseases are used to study the impact of dysregulated genes and cells. Use different genetic diseases (including cancer if you wish) from this course to provide specific examples of the following course topics:

(a) RNAi

(b) DNA methylation

(c) histone modification or chromatin proteins

Make sure to identify specific mechanisms from the diseases and link them back to the course content wherever possible.

2. Epigenetics and complex gene regulation have fundamentally altered the way we deal with bioinformatics and biotechnology. Give specific examples from this course that disprove the following old beliefs:

(a) phenotype is controlled by genotype (i.e. DNA sequence)

(b) cancer cell lines are useful models for studying normal gene regulation

(c) the 99% of our DNA that is never translated to protein is “garbage”

(Hey you! Yes you, student. This is a very open and general question. You must give specific examples from this course in your answer. Don’t give me generalities. Generalities are for undergrads. You are in a graduate program. Do I make myself clear?)


Answered Same DayDec 11, 2021

Solution

Rimsha answered on Dec 13 2021
60 Votes
Running Head: BIOLOGY (BIOTECHNOLOGY)    1
BIOLOGY (BIOTECHNOLOGY)        4
BIOLOGY (BIOTECHNOLOGY)
Table of Contents
1a. RNAi    3
1b. DNA Methylation    3
1c. Histone Modification or Chromatin Protein    3
2a. Phenotype is controlled by Genotype (i.e. DNA Sequence)    4
2b. Cancer Cell Lines are Useful Models for Studying Normal Gene Regulation    4
2c. The 99% of our DNA that is Never Translated to Protein is “Ga
age”    4
1a. RNAi
In Huntington’s disease, gene silencing using RNA interference is one of the most effective therapeutic approach. Huntington’s disease is progressive inherited disease in which
eakdown of nerve cells occur in the
ain. This resulted into functional and cognitive disability in the individual. This disease is caused by mutation in the HTT gene, which resulted in production of abnormally large protein that accumulated in nerve cells and resulted in their death. RNAi decreases the production of protein by degrading the mRNA as they consist of the gene information and act as template for the protein production.
1b. DNA Methylation
DNA methylation is used for the treatment of the Fragile X syndrome. Fragile X...
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