1. Diseases are used to study the impact of dysregulated genes and cells. Use different genetic diseases (including cancer if you wish) from this course to provide specific examples of the following course topics:
(a) RNAi
(b) DNA methylation
(c) histone modification or chromatin proteins
Make sure to identify specific mechanisms from the diseases and link them back to the course content wherever possible.
1. Diseases are used to study the impact of dysregulated genes and cells. Use different genetic diseases (including cancer if you wish) from this course to provide specific examples of the following course topics:
(a) RNAi
(b) DNA methylation
(c) histone modification or chromatin proteins
Make sure to identify specific mechanisms from the diseases and link them back to the course content wherever possible.
2. Epigenetics and complex gene regulation have fundamentally altered the way we deal with bioinformatics and biotechnology. Give specific examples from this course that disprove the following old beliefs:
(a) phenotype is controlled by genotype (i.e. DNA sequence)
(b) cancer cell lines are useful models for studying normal gene regulation
(c) the 99% of our DNA that is never translated to protein is “garbage”
(Hey you! Yes you, student. This is a very open and general question. You must give specific examples from this course in your answer. Don’t give me generalities. Generalities are for undergrads. You are in a graduate program. Do I make myself clear?)