The following is a list
of drugs. For this assignment, use any resources available to you to find...

Question

The following is a list
of drugs. For this assignment, use any resources available to you to find the
structures of these drugs and then identify the functional group or groups in
each molecule that is significantly ionized (>0.1%) at physiological pH
(7.4) and give an approximate pKa value for each functional group (+/- 1 pKa
unit).Atropine

Ephedrine
 Phenobarbital
 Cocaine
 Morphine
 Warfarin

For example, a functional group that
exhibits a basic pKa of 4.4 is significantly ionized at pH 7.4 while a
functional group that exhibits an acidic pKa of 10.4 is significantly ionized
at pH 7.4 but those are the limiting pKa values for meeting the criteria.

Robert · Accepted Answer

Solution: PPa040913_111028_1Final
Atropine: 
N
O
O
Me
OH
Tertiary amine group

Ephedrine: 
H
N
Me
OH
Me
Secondary amine group

Phenobarbital:
HN NH
O
O
Me
O
Imide group
Imide group
Cocaine: 
N O
Me
O
O
O
Me
Tertiary amine group

Morphine: 
O
HO
HO
N Me
Phenolic hydroxyl group
Tertiary amine group

Warfarin: 
O
Me
O
O
OH
Allylic hydroxyl group

The functional groups circled above are responsible for acidity or basicity of the 
respective compounds.

The following is a list of drugs. For this assignment, use any resources available to you to find the structures of these drugs and then identify the functional group or groups in each molecule that...

Solution

Answer To This Question Is Available To Download

Related Questions & Answers

Submit New Assignment