Sickle-cell anemia is caused by a genetic defect that
substitutes valine for glutamic acid at one...

Question

Sickle-cell anemia is caused by a genetic defect that 
substitutes valine for glutamic acid at one position 
in two of the four chains of the hemoglobin protein. 
The result is a decrease in the water solubility of 
hemoglobin. Examine the structures of valine and 
glutamic acid and explain why this might be so

Robert · Accepted Answer

Answers:-
The structure of Valine is given below,
O
NH2
CH3
CH3
OH
The structure of glutamic acid is given below,
O O
NH2
OHOH
As the structure reveals that glutamic acid has two -COOH group whereas
valine has only one -COOH group.

Sickle-cell anemia is caused by a genetic defect that substitutes valine for glutamic acid at one position in two of the four chains of the hemoglobin protein. The result is a decrease in the water...

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