Results (Part 1):Melting point of Aspirin: 120 0CInitial weight: 1.99 gFinal weight: 2.31 gResults...

Question

Results (Part 1):Melting point of Aspirin: 120 0CInitial weight: 1.99 gFinal weight: 2.31 gResults (Part 2):Weight: 3.19 gMelting point: 163 0C (approximately)

David · Accepted Answer

SYNTHESIS OF ASPIRIN AND SALICYLIC ACID 
ABSTRACT:  
Aspirin is an analgesic drug developed in the early history to alleviate pain. This is 
one of the most widely used drugs in the history of human kind. It is having less side 
effects and very fast acting. Aspirin is chemically acetyl salicylic acid. It is also an 
antipyretic drug, which is used to relieve pain and also function as an anti 
inflammatory medication. It belongs to the category of Non Steroid Anti Inflammatory 
Drugs.  This can be prepared from salicylic acid by acetylation. The yield is noted 
and compared with the theoretical yield. The melting point was noted for checking 
the purity of the product. Similarly, salicylic acid was prepared from methylsalicylate, 
whose theoretical yield was noted and reported along with their melting point values. 
INTRODUCTION 
This experiment has two steps. 
1. Preparation of Aspirin from Salicylic Acid 
Salicylic acid is a commonly available chemical and from it, aspirin can be 
synthesised. Salicylic acid is ortho-hydroxybenzoic acid. This can be acetylated 
using acetic anhydride in presence of concentrated sulphuric acid to form aspirin. 
Acetic anhydride acts as the source of acetyl group. 
Acid anhydrides or simply anhydrides are acid derivatives that contain two 
acyl group joined by an oxygen atom. When carboxylic acids are heated strongly, 
they produce acid anhydrides by a condensation reaction (overall loss of water from 
two molecules). The equation given below is for the reaction that produces acetic 
anhydride from acetic acid.
CH3C
O
OH
acetic acid (common)
ethanoic acid (IUPAC)

2 CH3C
O
O CCH3
O
acetic anhydride (common)
ethanoic anhydride (IUPAC)
 
The name of an anhydride is the name of the acid from which it is derived 
followed by anhydride. For example, acetic anhydride is the anhydride from acetic 
acid, and propanoic anhydride is the anhydride from propanoic acid. 
When an acyl group is transferred from one chemical species to another, the 
reaction is referred to as an acylation reaction.

Results (Part 1): Melting point of Aspirin: 120 0C Initial weight: 1.99 g Final weight: 2.31 g Results (Part 2): Weight: 3.19 g Melting point: 163 0C (approximately)

Solution

Answer To This Question Is Available To Download

Related Questions & Answers

Submit New Assignment