Question #1: (10 Marks)
The plant-derived terpene natural product ent-kaurenoic acid (shown below) has shown
promising bioactivity.
Experiments conducted by Adriana Lopes and co-authors (Phytochemistry Letters 2016, 18,
162-167 — available in UMLearn) established the biosynthetic pathway of ent-kaurenoic acid
using 13C–labelled glucose.
Please describe in your own words, the experiments that demonstrated the
biosynthesis of ent-kaurenoic acid in Smallanthus sonchifolius.
Feel free to include as many figures and schemes as you need to explain the results —
BUT: they must be original drawings (not copied directly from the source paper).
Feel free to consult any other source material that helps you describe the experiments
— but please be certain to add them as a reference to your assignment submission.
Maximum Length = Two Pages — plus references.
The assignment submission should be completed in MS Word with embedded figures and
structures as part of the two pages. All chemical structures must be drawn in ChemDraw.
CO2H
ent-kaurenoic acid