AMPK is the AMP sensitive protein kinase.Describe & explain the role of AMPK in altering cell...

Question

AMPK is the AMP sensitive protein kinase.Describe & explain the role of AMPK in altering cell signalling in response to changing levels of AMP [ 50%].Explain the impact of activation of AMPK on the rate of cellular metabolism [50%].

David · Accepted Answer

Discussion question: Describe & explain the role of AMPK in altering cell signalling in response to changing levels of AMP. Explain the impact of activation of AMPK on the rate of cellular metabolism?
Role of AMPK in altering cell signalling in response to changing levels of AMP
AMPK is the AMP activated protein kinase plays crucial role in altering cell signalling in accordance to the change in the levels of AMP. It is worth mentioning that AMPK performs the role of intracellular energy sensor controlling and ensuring appropriate energy balance within the cell. The findings showed that change in the levels of AMP influences and determine activation of leptin and adiponectin in muscles and liver evidencing control of peripheral tissues. AMP activated protein kinase plays master role in altering cell signalling (Cordero & Viollet, 2016). 
The kinase gets activated in accordance to the change in level of AMP. Any kind of change in the level of AMP deplete supplies such as low glucose, hypoxia, ischemia, etc alters cell signalling. AMP levels fluctuate in the degree of high and low as a cellular energy sensor, which brings both positive and negative alteration in the cell signalling. AMPK activation positively regulates cell signalling through replenishing AMP supplies, in terms of fatty acid oxidation and autophagy. AMPK also impacts cell signalling through AMP consuming biosynthetic processes such as gluconeogenesis, lipid and protein synthesis (Schwanstecher, 2011). 
AMPK alters cell signalling through direct phosphorylation of several enzymes for regulating and performing transcriptional control of metabolism. Due to its role as a central regulator in altering cell signalling, AMPK is considered as potential therapeutic target for regulating and managing change in the levels of AMP. In this way, it is argued that AMPK gets activated and contributes in altering cell signalling in response to an increase in AMP within the cell (Cordero & Viollet, 2016). AMP assumes the responsibility of activating AMPK along with protecting enzymes against dephosphorylation. AMPK comprises a catalytic α subunit and regulatory β subunits. It functions through all these subunits and regulated cell signalling (Daly, 2012). 
It has identified that AMPK is usually defined in ubiquitously manner and considered as a key mechanism regulating metabolic pathways named as fatty acid and cholesterol synthesis.

AMPK is the AMP sensitive protein kinase.Describe & explain the role of AMPK in altering cell signalling in response to changing levels of AMP [ 50%].Explain the impact of activation of AMPK on the...

Solution

Answer To This Question Is Available To Download

Related Questions & Answers

Submit New Assignment