RX 351 Lab - Module 6 Assignment (30pts)
Name _______________________________________________________________
Complete and submit on Canvas. You must show all work to receive full credit. Do not leave off units and make sure to use leading zeros. Dropping units in your answer or failure to use a leading zero in an answer will result in no credit for that answer, even if the number itself is co
ect.
Metronidazole is an antibiotic that is used orally, intravenously and topically. When compounding a pediatric oral suspension, it is typical to use metronidazole tablets as the source of the API, like in this formulation:
Rx
Metronidazole 500mg tablets
Chocolate Flavoring
Dark Che
y Flavoring
Bitter Suppressant
#10
5gtts
5gtts
2gtts
Ora-Blend Vehicle
qs ad 100ml
1. (2pts) How many metronidazole 500mg tablets would you need to prepare 8 fluid ounces of this suspension?
2. (2pts) If a pediatric patient takes ½ teaspoonful of this oral suspension q8h, how many milligrams of metronidazole will she receive per day?
3. (8pts) Refer to your textbook, Contemporary Pharmacy Practice, and read the sections on mortars and pestles in Chapter 13. Describe the different types of mortars.
4. (2pts) Which of the mortars would be a good choice to crush the tablets to prepare the metronidazole suspension? Explain your choice.
5. (2pts) Refer to Chapter 25 of your Contemporary Pharmacy Practice textbook, Section V.
a. What is the general term for the process of reducing particle size?
. What is the term for reducing particle size in a mortar with a pestle?
6. (2pts) Metronidazole is a notoriously bitter-tasting drug. This recipe uses two flavorings and a bitter suppressant product to mitigate the bad taste. Refer to Chapter 20 in your Contemporary Pharmacy Practice textbook, Section II. What methods could the caregive
parent of the child use to help with the bad taste?
7. (3pts) The ester form of metronidazole, metronidazole benzoate, does not have the same bitterness issue sue to its very low water solubility. Metronidazole benzoate is available in powder form. How many grams of metronidazole benzoate would be needed to prepare 8 fluid ounces of the formulation (above) such that the patient would receive an equivalent dose of the API?
Metronidazole MW=171.16; Metronidazole Benzoate MW=275.26
Weigh _____________g of metronidazole benzoate powder on electronic balance. (Round appropriately.)
8. (3pts) Calculate the w/v% concentration of sodium hydroxide in this Liquid Caustic solution.
9. (3pts) You are preparing benzalkonium chloride 1:1,000 for use as a topical antiseptic. Your pharmacy has 1 fl oz of ZEPHIRAN (benzalkonium chloride) 17% w/v solution in stock. If you used the whole fluid ounce of solution, how many liters of the antiseptic solution could you make?
10. (3pts) You prepare 500ml of 3% w/v phosphoric acid solution by mixing 85% w/w phosphoric acid (SG of solution=1.7) with purified water. How many milliliters of the acid solution do you need? Indicate what size of graduated cylinder you will use. Round appropriately.
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RX 351 Lab - Module 7 Assignment (20pts)
Name _______________________________________________________________
Complete and submit on Canvas. You must show all work to receive full credit. Do not leave off units and make sure to use leading zeros. Dropping units in your answer or failure to use a leading zero in an answer will result in no credit for that answer, even if the number itself is co
ect.
1. (20pts) A 35-year-old man addicted to morphine is in the early stages of withdrawal, with diaphoresis and extreme agitation. His doctor ordered an injection of Myer’s Cocktail, a combination of vitamins and minerals to mitigate the withdrawal symptoms. Prepare one dose (25ml) of the formulation for this patient.
Rx
Calcium (elemental)
23.25mg
Magnesium (elemental)
Vitamin B12 (cyanocobalamin)
Pyridoxine
Dexpanthenol (Vitamin B5)
Vitamin C (asco
ic acid)
SWFI
95.15mg
750mcg
150mg
250mg
4.44g
qs 25ml
Administration: Inject over 15 minutes through a 25G needle
SOURCES OF APIs
Calculated Volume
Syringe Size
Measured Volume
Note that the injection solution contains the dihydrate form calcium chloride. Atomic Weights: Ca=40; Cl=35.5; H=1; O=16
Note that the injection solution contains the hexahydrate form of magnesium chloride. Atomic Weights: Mg = 24.3
Cl=35.5; H=1; O = 16
Give answers for both ingredients.
Can use 2 syringes to obtain necessary volume.
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