RX 351 Lab - Module 5 Assignment (28pts)
Name _______________________________________________________________
Complete and submit on Canvas. You must show all work to receive full credit. Do not leave off units and make sure to use leading zeros. Dropping units in your answer or failure to use a leading zero in an answer will result in no credit for that answer, even if the number itself is co
ect.
1. (4pts) A 70.5lb pediatric patient is ordered cefazolin 550mg IV q8h x 5 days to treat a case of cellulitis. Use the dosing regimen here (copied from the drug monograph) to determine if this dosing regimen is appropriate for this patient.
Skin and soft tissue infections, S. aureus, methicillin susceptible (mild to moderate): Infants, Children, and Adolescents:
S. aureus, methicillin susceptible skin and soft tissue infections including pyomyositis: IV: 50 mg/kg/day divided every 8 hours; maximum dose: 1,000 mg/dose; higher doses may be required in severe cases; duration of therapy at least 5 days, but longer may be necessary in some cases, e.g., fe
ile and neutropenic patients: 7 to 14 days; pyomyositis: 14 to 21 days
As ordered by prescriber, patient would receive _________mg/kg/day of cefazolin divided q ______hours for _______ days.
Initial here if daily dose (on mg/kg basis), frequency, and duration fall within the recommended guidelines: _____________
(Acceptable is within 5% of recommended dose, in this scenario.)
If dose is not acceptable, explain here:
Answer the following questions and process the med order for patient David Lee’s intermittent infusion.
Med Orders (adult patient with NKDA)
D5 ½ NS @ 50ml/h
Clindamycin 600mg IV q6h
2. (2pts) What is the concentration of the two ingredients in this patient’s primary IV solution?
3. (1pt) What size(s) of this IV solution are available in your storeroom?
4. (2pts) If the first IV bag is started at 0500 this AM, what day/time would the second bag be started? What day/time would the third bag be started? Express in military time.
Go to Lexi-Comp and find information regarding PREPARATION and ADMINISTRATION of clindamycin.
DRUG INFORMATION:
5. (1pt) Acceptable Diluents (circle one or both) : D5W NS
6. (1pt) Acceptable Diluent Volume (list all IV bag sizes that are acceptable):
7. (1pt) Choose an IV bag from the storeroom list to use for this order (list diluent and size of bag).
8. (2pts) What is the recommended time for infusing a dose of this medication? ______________________
CALCULATIONS:
You will use the vial pictured here to prepare a 24-hour
supply of doses (you may need more than one vial.)
9. (2pts) Dose Volume = __________ml (volume of drug solution to prepare one dose)
10. (2pts) Based on the recommended time for infusion, calculate a flow rate for administering this drug.
Flow Rate: ____________ml/h
11. (5pts) Complete the instructions for compounder to prepare three doses of clindamycin. Round volume appropriately based on cali
ation of syringe. Include specific information regarding supplies in innstructions (size of syringe, diluent solution, size of IV bag, etc).
Instructions for Compounder:
12. (5pts) Complete the required information on the IV label (that would be attached to each of the three IV bags). Use the information from the IOI Part 3 slide set to guide you.
MR# MR42222
General Hospital
David Lee
DOB: 3/8/20xx
22yo M
Provider:
Manuel Bachman, MD
Dose:
Route:
IV
First Dose Due:
Frequency:
Alerts:
All: NKDA
Storage:
Expiration Date:
Manufacture
Lot#:
Pharmacist:
Instructions:
1
Pharmaceutical Calculations 15
https:
t.me/MedicalBooksStore
Pharmaceutical Calculations
15 h Edit ion
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H war C. A sel, Phd
Professor and Dean Emeritus
College of Pharmacy
University of Georgia
Athens, Georgia
Shelly J. S ck , Phd, RPh
Professo
College of Pharmacy
Southwestern Oklahoma State University
Weatherford, Oklahoma
Pharmaceutical
Calculations
15 h Edit ion
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Senior Acquisitions Editor: Tari Broderick
Product Development Editor: Stephanie Roulias
Production Project Manager: Priscilla Crate
Designer: H olly McLaughlin
Manufacturing Coordinator: Margie Orzech
Marketing Manager: Lisa Zoks
Prepress Vendor: SPi Global
15th Edition
Copyright © 2017 Wolters Kluwe
Copyright © 2013 Wolters Kluwer H ealth | Lippincott Williams & Wilkins. Copyright © 2010, 2006, 2001,
1996, 1991, 1986 by Lippincott Williams & Wilkins. All rights reserved. T his book is protected by copyright.
N o part of this book may be reproduced or transmitted in any form or by any means, including as photocopies or
scanned-in or other electronic copies, or utilized by any information storage and retrieval system without writ-
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ief quotations embodied in critical articles and reviews.
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our website at lww.com (products and services).
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Printed in China
Li
ary of Congress Cataloging-in-Publication D ata
N ames: Ansel, H oward C., 1933- , author. | Stockton, Shelly J., author.
T itle: Pharmaceutical calculations / H oward C. Ansel, Shelly J. Stockton.
Description: 15th edition. | Philadelphia : Wolters Kluwer, [2016] | Includes
bibliographical references and index.
Identifiers: LCCN XXXXXXXXXX | ISBN XXXXXXXXXXalk. paper)
Subjects: | MESH : Drug Dosage Calculations. | Pharmaceutical
Preparations—administration & dosage.
Classification: LCC RS57 | N LM Q V 748 | DDC 615.1/401513—dc23 LC record available at http:/ / lccn.loc.
gov/ XXXXXXXXXX
T his work is provided “as is,” and the publisher disclaims any and all wa
anties, express or implied, including any
wa
anties as to accuracy, comprehensiveness, or cu
ency of the content of this work.
T his work is no substitute for individual patient assessment based upon healthcare professionals’ examination of
each patient and consideration of, among other things, age, weight, gender, cu
ent or prior medical conditions,
medication history, laboratory data and other factors unique to the patient. T he publisher does not provide medi-
cal advice or guidance and this work is merely a reference tool. H ealthcare professionals, and not the publisher,
are solely responsible for the use of this work including all medical judgments and for any resulting diagnosis and
treatments.
Given continuous, rapid advances in medical science and health information, independent professional verifica-
tion of medical diagnoses, indications, appropriate pharmaceutical selections and dosages, and treatment options
should be made and healthcare professionals should consult a variety of sources. W hen prescribing medication,
healthcare professionals are advised to consult the product information sheet (the manufacturer’s package insert)
accompanying each drug to verify, among other things, conditions of use, warnings and side effects and identify
any changes in dosage schedule or contraindications, particularly if the medication to be administered is new,
infrequently used or has a na
ow therapeutic range. To the maximum extent permitted under applicable law, no
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v
Preface
T he 15th edition of Pharmaceutical Calculations marks the introduction of Professor Shelly
Stockton as co-author. Professor Stockton’s experience in pharmacy practice and her exper-
tise in teaching pharmaceutics and pharmacy calculations are reflected in her substantial
contributions to this textbook. Combined with the many progressive changes recom-
mended by a select review team of pharmacy students, practitioners, and educators, this new
edition maintains the standard for today’s academic and basic practice requirements in the
subject area of pharmaceutical calculations.
Each chapter has been thoroughly revised with the focus directed toward providing
asic pharmaceutical calculations along with supporting explanations of the pharmaceutical
or clinical purpose underpinning each type of calculation. H undreds of new problems have
een added to include many cu
ent products encountered in pharmacy practice. Relevance
is further demonstrated by the inclusion of select product labels directly linked to example
problems. N ew in this edition are Authors’ Extra Points that provide
ief explanations of
select underlying subjects, as: pharmacopeias, electronic prescriptions, drug names, and the regu-
lation of pharmacy compounding. A section on equianalgesic dosing for narcotic analgesics has
een added to Chapter 10 along with dosing tables related to the subject.
All of the valued features of the previous edition have been retained and enhanced,
including the following: in-chapter example problems with step-by-step solutions; end-of-
chapter practice problems with answers; Case-in-Point features that provide clinical or phar-
maceutical case studies; Calculations Capsules that provide boxed summaries of chapter
calculations; CalcQuiz sections that provide a limited number of unsolved problems, useful as
homework, quiz, or assessment exercises; and, the Comprehensive Review Problems at the end
of the book that provide multipart solved problems for student use as a final self-assessment.
T hroughout its history, this textbook has served as a valuable resource in meeting the
instructional needs of pharmacy students in the area of pharmaceutical calculations. T his
new edition is expected to continue to meet that need.
Compan on Web s te
Pharmaceutical Calculations, 15th edition, includes additional resources for both instructors and
students, available on the book’s companion Web site at http:
thePoint.lww.com/Ansel15e.
Resources for Students
• Interactive math calculations Q uiz Bank, with more than 400 review problems and
detailed solutions
Resources for instructors
• CalcQ uiz Solutions
• Searchable Full Text Online
See the inside front cover for more details, including the passcode you will need to gain
access to the Web site.
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vii
Acknowledgments
T he author gratefully acknowledges the contributions to this revision by the following per-
sons: Tom Schoenbachler, for insights into contemporary community pharmacy practice;
Deborah Elder, for contributions in the area of pharmacy compounding; Ken Duke, for
problems in the area of nuclear pharmacy; Wa
en Beach, for some Case-in-Point calcula-
tions; Flynn Wa
en, for a host of problems including many relating to institutional phar-
macy practice; Michael Ansel and Catherine Chuter, for information on the verification and
data processing of electronic prescriptions; Les Ramos and Margaret Ramos, for their input
in various areas of clinical calculations; H ardeep Saluja and Sarai Flynn for contributions to
the chapter on bioavailability and pharmacokinetics; Patra Kositchaiwat and Ryan Varghese
for their input in the area of electrolyte solution calculations; and Loyd V. Allen, Jr. for
his continued courtesy in allowing use of formulas published in the International Journal of
Pharmaceutical Compounding.
Gratitude is expressed to the following reviewers, whose experience was drawn upon
during the planning process and whose thoughtful analysis and constructive comments led
to many of the changes in this revision: Stacy Cairns, Kimberly Daugherty, David Dubins,
H eather Gegenhuber, N ancy Kleiman, William Kolling, Kimberly N guyen, and T ien Phan.
Particular thanks are offered to Tari Broderick, Senior Acquisitions Editor, and
Stephanie Roulias, Product Development Editor, for their support and guidance during the
evision process and to the other exceptional people at Wolters Kluwer H ealth | Lippincott
Williams & Wilkins for their work in the design, preparation, and production of this revi-
sion. Finally, special appreciation is extended to Tom Conville for his expertise in copyedit-
ing and assistance in resource development.
Howard C. Ansel
Athens, Georgia
Shelly J. Stockton
Weatherford, Oklahoma
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ix
Preface v
Acknowledgments vii
Introduction xi
1 Fundamentals of Pharmaceutical Calculations ..................................... XXXXXXXXXX1
2 International System of Units ............................................................. XXXXXXXXXX17
3 Pharmaceutical Measurement .................................................................