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***4D-710 ( Cystic Fibrosis) will be attached*** I need an Prior Art Search/IP Landscape conducted on 4D-710, the case 4D-710 will be attached as a resource The following websites are to be used ...

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***4D-710 ( Cystic Fibrosis) will be attached***

I need an Prior Art Search/IP Landscape conducted on 4D-710, the case 4D-710 will be attached as a resource

The following websites are to be used

USPTO - https://patft.uspto.gov/netahtml/PTO/search-bool.html

WIPO IP - https://patentscope.wipo.int/search/en/search.jsf

Free Patents Online https://www.freepatentsonline.com

***This is just a sample of a what is expected in the prior art search***

Prior Art Search/IP Landscape

Prior art search produced no known patents for the treatment of Stargardt Disease using drug therapy. The IP landscape was thoroughly searched against formal protections for a known drug therapy related to the treatment of Stargardt Disease. Formal patent protection for drug therapy related to the treatment of Stargardt Disease was searched using the following patent search engines: USPTO, WIPO IP, and Free Patents Online. The following terms were searched both exclusively and in tandem as to include all relevant information related to the IP landscape of the drug profile in question (NSR-ABCA4): Stargardt Disease, ABCA4, AAV, Viral Gene Therapy, CRISPR, Dual AAV Vector. There are currently less than 150 patents that mention both Stargardt Disease AND AAV gene therapy, however, there are exactly 0 other patents that report on drug therapy for the treatment of Stargardt Disease.

It should be noted that there does exist several patents that describe compositions and methods for the treatment of Stargardt Disease using viral gene therapy. According to the drug profile used for this assignment, “The gene therapy program utilizes a technology developed at Oxford University to target ABCA4 protein”. The following patents identify and describe this gene therapy and were discovered on Free Patents Online and PatentScope, respectively. Biogen is listed in concordance with the inventors at Oxford University as the holders of United States Patent Application XXXXXXXXXXidentifying a dual overlapping adeno-associated viral vector system for expressing ABCA4. In a separate patent holding WO XXXXXXXXXX, Nightstar (now owned by Biogen) in concordance with the inventors at Oxford University, describe the viral vector technology for gene therapy of Stargardt Disease aforementioned in the drug profile, NSR-ABCA4.

Answered 1 days After Jan 26, 2022

Solution

Garima answered on Jan 28 2022
123 Votes
4D-710 drug treatment for Cystic Fi
osis is DNA based gene therapy using co
ected codon optimised CFTR transgene delivered through lung targeted adeno-associated virus. The technology claims to use adeno-associated viral vector, A101 (4DMT Press release, 2021), to ca
y function copy of CFTR transgene, also called microCFTR, to make CFTR protein. This technology claims to be resistant to pre-existing AAV antibodies and the route of delivery is aerosol based inhalation into lungs crossing the mucous ba
ier. The drug treatment exists for cystic fi
osis are either not effective in 10-15% patients or even if they are effective they are not able to fully restore the lung functions (Fajac and Boeck, 2017). The existing treatments in the United States for cystic fi
osis are non-DNA based. The technology was developed initially for patients in the 10-15% category that do not get relief from the existing therapies of cystic fi
osis, however, the company claims that the technology has the potential to treat
oad cystic fi
osis patient population. The preclinical data from non-human primates were presented at the American Society for Gene and Cell Therapy (ASGCT) 24th Annual Meeting (4DMT Press release, 2021).
Prior art search produced no known patents in the United States for the treatment of cystic fi
osis using AAV-based DNA gene therapy drug therapy (4D-710). The IP landscape was thoroughly searched on United States Patent and trademark office USPTO - https:
patft.uspto.gov/netahtml/PTO/search-bool.html. The following terms were searched both exclusively and in tandem as to include all relevant information related to the IP...
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